Electroretinography in central retinal vein occlusion: correlation of electroretinographic changes with pupillary abnormalities

• Published in: Graefe's archive for clinical and experimental ophthalmology 1989-01, Vol.227 (6), p.549-561
• Main Authors: HAYREH, S. S, KLUGMAN, M. R, PODHAJSKY, P, KOLDER, H. E
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Analysis of Variance; Biological and medical sciences; Electrodiagnosis. Electric activity recording; Electrooculography. Electroretinography; Electroretinography; Eye - blood supply; Follow-Up Studies; Glaucoma - complications; Glaucoma - physiopathology; Humans; Investigative techniques, diagnostic techniques (general aspects); Ischemia - diagnosis; Medical sciences; Middle Aged; Neovascularization, Pathologic - diagnosis; Neovascularization, Pathologic - physiopathology; Predictive Value of Tests; Prospective Studies; Pupil Disorders - diagnosis; Pupil Disorders - physiopathology; Regression Analysis; Retinal Vein Occlusion - classification; Retinal Vein Occlusion - complications; Retinal Vein Occlusion - diagnosis; Retinal Vein Occlusion - physiopathology
• ISSN: 0721-832X; 1435-702X
• DOI: 10.1007/BF02169451

In 149 eyes with central retinal vein occlusion (CRVO), we prospectively investigated the role of routine, clinical electroretinography (ERG) in differentiating ischemic (60 eyes) from nonischemic CRVO (89 eyes). Single-flash photopic and scotopic ERGs were recorded. Data for the amplitudes and implicit times of a- and b-waves and for the b-/a-wave amplitude ratio were analyzed in detail. The study revealed that the best ERG parameter (for both photopic and scotopic ERG) for differentiating ischemic from nonischemic CRVO was a subnormal b-wave amplitude (reduced to less than or equal to 60% or by greater than or equal to 1 SD from the normal mean value, or less than or equal to 64%-69% of that in the fellow normal eye), with a sensitivity of 80%-90% and a specificity of 70%-80%. ERG findings were correlated with the relative afferent pupillary defect (RAPD). An RAPD of greater than or equal to 0.7 log units showed a sensitivity of 88% and a specificity of 90% in differentiating ischemic from nonischemic CRVO. ERG and RAPD findings showed a good correlation. The combined ERG and RAPD tests could differentiate 97%-100% of ischemic from nonischemic CRVO cases, with a specificity of about 70%.