Aqueous oxygen : A highly O2-Supersaturated infusate for regional correction of hypoxemia and production of hyperoxemia

High levels of hyperoxemia may have utility in the treatment of regional tissue ischemia, but current methods for its implementation are impractical. A catheter-based method for infusion of O2, dissolved in a crystalloid solution at extremely high concentrations, ie, 1 to 3 mL O2/g (aqueous oxygen [...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1997-12, Vol.96 (12), p.4385-4391
Main Authors: SPEARS, J. R, BING WANG, XIAOJUN WU, PRCEVSKI, P, JIANG, A. J, SPANTA, A. D, CRILLY, R. J, BRERETON, G. J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Coronary Circulation - physiology
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Dogs
Female
Hypoxia - drug therapy
Medical sciences
Myocardial Ischemia - drug therapy
Myocardial Ischemia - physiopathology
Oxygen - administration & dosage
Oxygen - blood
Oxygen - pharmacology
Oxygen - therapeutic use
Rabbits
Solutions
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Summary:High levels of hyperoxemia may have utility in the treatment of regional tissue ischemia, but current methods for its implementation are impractical. A catheter-based method for infusion of O2, dissolved in a crystalloid solution at extremely high concentrations, ie, 1 to 3 mL O2/g (aqueous oxygen [AO]), into blood without bubble nucleation was recently developed for the potential hyperoxemic treatment of regional tissue ischemia. To test the hypotheses that hypoxemia is correctable and that hyperoxemia can be produced locally by AO infusion, normal saline equilibrated with O2 at 3 MPa (30 bar; 1 mL O2/g) was delivered into arterial blood in two different animal models. In 15 New Zealand White rabbits with systemic hypoxemia, AO was infused into the midabdominal aorta at 1 g/min. Mean distal arterial PO2 increased to 236+/-113 and 593+/-114 mm Hg on 1-hour periods of air and O2 breathing, respectively, from a baseline of 70+/-10 mm Hg (P.05) in temporal changes in blood counts and chemistries were identified. In 10 dogs, low coronary blood flow in the circumflex artery was delivered with a roller pump through the central channel of an occluding balloon catheter. Hypoxemic, normoxemic, and AO-induced hyperoxemic blood perfusates (mean PO2, 52+/-4, 111+/-22, and 504+/-72 mm Hg, respectively) were infused for 3-minute periods in a randomized sequence. Short-axis two-dimensional echocardiography demonstrated a significant decrease (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.96.12.4385