Effects of calcium on left ventricular function early after cardiopulmonary bypass

Objectives: Evaluation of the effects of intravenous CaC1 2on systolic and diastolic function early after separation from cardiopulmonary bypass (CPB) Design: Prospective study Setting: University hospital Participants: Twenty patients scheduled for elective coronary artery surgery Interventions: Le...

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Bibliographic Details
Published in:Journal of cardiothoracic and vascular anesthesia 1997-12, Vol.11 (7), p.864-869
Main Authors: DeHert, Stefan G., Ten Broecke, Pieter W., De Mulder, Peter A., Rodrigus, Inez E., Haenen, Luc R., Boeckxstaens, Christiane J., Vermeyen, Karel M., Gillebert, Thierry C., Moulijn, Adriaan C.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
calcium
Calcium - pharmacology
Cardiopulmonary Bypass
Cardiotonic agents
Cardiovascular system
coronary surgery
Diastole - drug effects
diastolic function
Female
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Prospective Studies
Stroke Volume - drug effects
Systole - drug effects
systolic function
Ventricular Function, Left - drug effects
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Summary:Objectives: Evaluation of the effects of intravenous CaC1 2on systolic and diastolic function early after separation from cardiopulmonary bypass (CPB) Design: Prospective study Setting: University hospital Participants: Twenty patients scheduled for elective coronary artery surgery Interventions: Left ventricular (LV) pressures were measured with fluid-filled catheters. Data were digitally recorded during pressure elevation induced by tilt-up of the legs. Transgastric short-axis echocardiographic views of the LV were simultaneously recorded on videotape. Measurements were obtained before the start of CPB, 10 minutes after termination of CPB, after intravenous administration of CaC1 2, 5 mg/kg, and 10 minutes later. Measurements and Main Results: Systolic function was evaluated with the slope (Ees, mmHg/mL) of the systolic pressure-volume relation. Diastolic function was evaluated with the chamber stiffness constant (Kc, mmHg/mL) of the diastolic pressure-volume relation. CaC1 2increased Ees from 2.62 ± 0.46 to 5.58 ± 0.61 (mean ± SD), but induced diastolic dysfunction with an increase in Kc from 0.011 ± 0.006 to 0.019 ± 0.007. These changes were transient and had disappeared within 10 minutes after administration of CaC1 2. Conclusions: CaC1 2early after CPB transiently improved systolic function at the expense of an increase in ventricular stiffness, suggesting temporary diastolic dysfunction.
ISSN:1053-0770
1532-8422
DOI:10.1016/S1053-0770(97)90122-1