Glomerular proliferating cell kinetics in acute post-streptococcal glomerulonephritis (APSGN)

• Published in: The Journal of pathology 1997-11, Vol.183 (3), p.359-368
• Main Authors: Oda, Takashi, Yoshizawa, Nobuyuki, Takeuchi, Akihiko, Nakabayashi, Iwao, Nishiyama, Junichiro, Ishida, Aki, Tazawa, Keiji, Murayama, Masahiro, Hotta, Osamu, Taguma, Yoshio
• Format: Article
• Language: English
• Subjects: Acute Disease; acute post-streptococcal glomerulonephritis; Adolescent; Adult; Bacterial diseases; Bacterial diseases of the urinary system; Biological and medical sciences; Cell Division; Child; Disease Progression; Female; glomerular cell proliferation; Glomerulonephritis - microbiology; Glomerulonephritis - pathology; Human bacterial diseases; Humans; immune cell infiltration; Immunoenzyme Techniques; Infectious diseases; Kidney Glomerulus - pathology; Male; Medical sciences; Middle Aged; PCNA; Proliferating Cell Nuclear Antigen - metabolism; Streptococcal Infections - complications
• ISSN: 0022-3417; 1096-9896
• DOI: 10.1002/(SICI)1096-9896(199711)183:3<359::AID-PATH939>3.0.CO;2-B

To investigate the time sequence of glomerular cell proliferation in acute human glomerulonephritis, renal biopsy tissues were examined from 15 acute post‐streptococcal glomerulonephritis (APSGN) patients (who were biopsied 1–31 days after onset), using an immunoperoxidase technique with monoclonal antibodies against proliferating cell nuclear antigen (PCNA) and various cell surface markers. Few, if any, PCNA+ cells were observed in normal glomeruli, but many cells were positive for PCNA in the acute phase of APSGN. Glomerular PCNA+ cells were observed either within glomerular tufts, or lining Bowman's capsule (parietal epithelial cells); the number of positive cells tended to decrease exponentially as the disease duration increased (r=−0·91, P