Preferential Localization of Human CD5+ B Cells in the Peritoneal Cavity

In a transgenic mouse model of autoimmune haemolytic anaemia, CD5+ B lymphocytes localized in the peritoneal cavity are shown to play an important role in the onset of autoimmune disease. The authors have examined whether CD5+ B cells are present in the peritoneal cavity of 12 human individuals with...

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Bibliographic Details
Published in:Scandinavian journal of immunology 1997-12, Vol.46 (6), p.541-545
Main Authors: NISITANI, S., MURAKAMI, M., AKAMIZU, T., OKINO, T., OHMORI, K., MORI, T., IMAMURA, M., HONJO, T.
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - cytology
B-Lymphocytes - immunology
CD5 Antigens - immunology
Cell Count
Female
Humans
Male
Mice
Peritoneal Cavity - cytology
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Summary:In a transgenic mouse model of autoimmune haemolytic anaemia, CD5+ B lymphocytes localized in the peritoneal cavity are shown to play an important role in the onset of autoimmune disease. The authors have examined whether CD5+ B cells are present in the peritoneal cavity of 12 human individuals with non‐invasive gastrointestinal tumours and found that in humans CD5+ B cells preferentially lodge in the peritoneal cavity as compared to the peripheral blood and spleen while the numbers of the peritoneal B lymphocytes in humans are much lower than in mice and vary widely between individuals.
ISSN:0300-9475
1365-3083
DOI:10.1046/j.1365-3083.1997.d01-166.x