Intestinal permeability to polyethylene glycol 4000 and porcine albumin in piglets infected with transmissible gastroenteritis virus

The intestinal permeability of specific pathogen free piglets has been studied by measuring the concentration of 14C in the blood after oral administration of 14C polyethylene glycol (14C PEG, MW = 4000) and the concentration of 131I in the faeces after intraperitoneal administration of 131I porcine...

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Bibliographic Details
Published in:Veterinary research communications 1989-01, Vol.13 (6), p.467-474
Main Authors: Vellenga, L. (Rijksuniversiteit Utrecht (Netherlands). Clinic for Large Animal Medicine), Wensing, T, Egberts, H.J.A, Dijk, J.E. van, Mouwen, J.M.V.M, Breukink, H.J
Format: Article
Language:English
Subjects:
Administration, Oral
ALBUMINAS
ALBUMINE
ALBUMINS
Albumins - administration & dosage
Animals
Feces - analysis
Gastroenteritis, Transmissible, of Swine - metabolism
Hematocrit - veterinary
INTESTIN
Intestinal Mucosa - metabolism
INTESTINES
INTESTINOS
Jejunum - pathology
LECHON
Permeability
PIGLETS
Polyethylene Glycols - administration & dosage
PORCELET
Specific Pathogen-Free Organisms
Swine
TRANSMISSIBLE GASTROENTERITIS VIRUS
VIRUS GASTROENTERITE DU PORC
VIRUS GASTROENTERITIS TRANSMISIBLE
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Summary:The intestinal permeability of specific pathogen free piglets has been studied by measuring the concentration of 14C in the blood after oral administration of 14C polyethylene glycol (14C PEG, MW = 4000) and the concentration of 131I in the faeces after intraperitoneal administration of 131I porcine albumin (131I PA, MW = 68,000). The tests were performed one day before and up to two days after the piglets were infected with transmissible gastroenteritis (TGE) virus. Jejunal biopsies were taken from two piglets before the experimental infection, from two piglets 12 h after the experimental infection and from five piglets at the end of the experiment, 46 h after infection. Blood samples were taken six-hourly and faecal samples several times. Some piglets vomited before diarrhoea and loss of appetite started at 14 h after infection; the packed cell volume decreased before but increased after infection. Morphological examination showed hyperregenerative villous atrophy at 46 h after infection. There was no increase in the permeation of 14C PEG but there was a significant increase in the flux of 131I PA from the blood to the gut lumen.
ISSN:0165-7380
1573-7446
DOI:10.1007/BF00402570