A COMPARISON OF HEPATIC CYTOCHROME P450 PROTEIN EXPRESSION BETWEEN INFANCY AND POSTINFANCY

We immunochemically measured the contents of 9 different cytochrome P450 (CYP) isoenzymes expressed in the liver and compared them between two groups: one group of 6 infant and 4 perinatal patients and one group of 10 patients after infancy (over 1 year old). CYP protein expressed in human liver can...

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Bibliographic Details
Published in:Life sciences (1973) 1997, Vol.61 (26), p.2567-2574
Main Authors: Tateishi, Tomonori, Nakura, Hironori, Asoh, Masako, Watanabe, Minoru, Tanaka, Masami, Kumai, Toshio, Takashima, Sachio, Imaoka, Susumu, Funae, Yoshihiko, Yabusaki, Yoshiyasu, Kamataki, Tetsuya, Kobayashi, Shinichi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aging - metabolism
Blotting, Western
Child
Child, Preschool
Cytochrome P-450 Enzyme System - metabolism
Female
Fetus - metabolism
Gestational Age
hepatic cytochrome P450
Humans
infancy
Infant
Infant, Newborn
Isoenzymes - metabolism
Liver - embryology
Liver - enzymology
Liver - growth & development
Male
Middle Aged
perinatal period
postinfancy
Western blotting
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Summary:We immunochemically measured the contents of 9 different cytochrome P450 (CYP) isoenzymes expressed in the liver and compared them between two groups: one group of 6 infant and 4 perinatal patients and one group of 10 patients after infancy (over 1 year old). CYP protein expressed in human liver can be divided into three groups on the basis of expression pattern: (a) CYP2A6, 2C9, 2D6, 2E1, and 3A were present in all samples and no difference was observed between the two groups; (b) CYP1A2, 2B6, and 2C8 were expressed more after infancy than during infancy; and (c) CYP3A7, which has been considered a major CYP enzyme in fetal liver microsomes, was expressed in all infants as well as the four perinatal patients, whereas it was detected in only 2 patients after infancy. These results implied that CYP2A6, 2C9, 2D6, 2E1, and 3A are already expressed during perinatal and infant period, while CYP1A2, 2B6, and 2C8 are expressed highly in subjects over 1 year old, and CYP3A7 disappeared after infancy.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(97)01011-4