An Age-Adjusted Trend Test for the Tumor Incidence Rate for Multiple- Sacrifice Experiments

The nonparametric age-adjusted trend test for the tumor incidence rate proposed by Malani and Lu (1993, Communications in Statistics-Theory and Methods 22, 1557-1584) is modified in two ways to improve the size of the test. First, the tumor incidence rate is constrained to be nonnegative, and second...

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Bibliographic Details
Published in:Biometrics 1997-12, Vol.53 (4), p.1467-1474
Main Authors: Kodell, Ralph L., Ahn, Hongshik
Format: Article
Language:English
Subjects:
Age Factors
Bioassay
Biometrics
Carcinogenicity
Case-Control Studies
Communication theory
Dosage
Humans
Incidence
Likelihood Functions
Maximum likelihood estimators
Monte Carlo Method
Musical intervals
Natural death
Neoplasms - epidemiology
Neoplasms - mortality
Probability
Shorter Communications
Statistical variance
Statistics, Nonparametric
Survival Analysis
Survival Rate
Tumors
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Summary:The nonparametric age-adjusted trend test for the tumor incidence rate proposed by Malani and Lu (1993, Communications in Statistics-Theory and Methods 22, 1557-1584) is modified in two ways to improve the size of the test. First, the tumor incidence rate is constrained to be nonnegative, and second, a conditional variance is used in place of the asymptotic variance based on the delta method. A Monte Carlo simulation study demonstrates the improvement in size of test. The proposed test can be viewed also as a modification of the two-group test of Dewanji and Kalbfleisch (1986, Biometrics 42, 325-341), although their maximum likelihood routine is based on a different formulation of the problem.
ISSN:0006-341X
1541-0420
DOI:10.2307/2533512