int‐2 Oncogene amplification and prognosis in node‐negative breast carcinoma

The role of int‐2 oncogene amplification on the prognosis of breast cancer patients was investigated in 128 patients with node‐negative primary breast cancers given first‐line local‐regional treatments until relapse and with a median follow‐up of 65 months. Tumours had been previously characterised...

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Bibliographic Details
Published in:International journal of cancer 1997-12, Vol.74 (6), p.620-624
Main Authors: Fioravanti, Laura, Cappelletti, Vera, Coradini, Danila, Miodini, Patrizia, Borsani, Giorgio, Daidone, Maria Grazia, Di Fronzo, Giovanni
Format: Article
Language:English
Subjects:
Analysis of Variance
Biological and medical sciences
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Breast Neoplasms - ultrastructure
Disease-Free Survival
DNA, Neoplasm - genetics
Female
Fibroblast Growth Factor 3
Fibroblast Growth Factors - genetics
Gene Amplification
Gynecology. Andrology. Obstetrics
Humans
Lymph Nodes - pathology
Mammary gland diseases
Medical sciences
Middle Aged
Prognosis
Proportional Hazards Models
Proto-Oncogene Proteins - genetics
Receptors, Estrogen - analysis
Tumors
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Summary:The role of int‐2 oncogene amplification on the prognosis of breast cancer patients was investigated in 128 patients with node‐negative primary breast cancers given first‐line local‐regional treatments until relapse and with a median follow‐up of 65 months. Tumours had been previously characterised for oestrogen (ER) and progesterone receptor (PgR) status and proliferative activity (3H‐thymidine labelling index). Amplification of the int‐2 oncogene occurred in 18% of cases and was significantly related to the presence of hormone receptors and to menopausal status or age, but not to proliferative status. Patients with tumours exhibiting int‐2 amplification had a lower probability of disease‐free survival than patients with non‐amplified tumours and frequently developed local‐regional recurrence. Disease‐free survival analysis, adjusted for the prognostic contribution provided by tumour size, steroid receptors and proliferative rate, indicated that the association between int‐2 amplification and risk of relapse was maintained and remained constant even in the presence of the other co‐variates. Interestingly, int‐2 amplification was a further prognostic discriminant within subsets of patients with a putatively good (i.e., tumour size
ISSN:0020-7136
1097-0215
DOI:10.1002/(SICI)1097-0215(19971219)74:6<620::AID-IJC11>3.0.CO;2-9