Regulatory functions of the phosphocarrier protein HPr of the phosphoenol pyruvate-dependent phosphotransferase system in Gram-positive bacteria

HPr of Gram-positive bacteria not only serves a catalytic function as phospho carrier protein within the PTS, but is also involved in the regulation of the uptake of PTS sugars and appears to be important to the regulation of uptake of glycerol in certain bacteria. Astonishing is the number of enzym...

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Bibliographic Details
Published in:FEMS microbiology reviews 1989-06, Vol.63 (1), p.167-174
Main Authors: Deutscher, Josef, Sossna, Gina, Gonzy-Treboul, Genevieve
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Amino Acid Sequence
Bacterial Proteins
Dihydroxyacetone - metabolism
Glycerol kinase
Glycerol Kinase - metabolism
Gram-Positive Bacteria - enzymology
HPr kinase
Inducer expulsion
Molecular Sequence Data
P-ser-HPr phosphatase
Phosphoenolpyruvate Sugar Phosphotransferase System - metabolism
phosphoenolpyruvate-carbohydrate phosphotransferase
Phosphorylation
protein HPr
Protein phosphorylation
Sequence Homology, Nucleic Acid
Seryl-phosphorylated HPr
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Summary:HPr of Gram-positive bacteria not only serves a catalytic function as phospho carrier protein within the PTS, but is also involved in the regulation of the uptake of PTS sugars and appears to be important to the regulation of uptake of glycerol in certain bacteria. Astonishing is the number of enzymes, with which this small protein of approximately 10 kDa can interact. HPr not only interacts with enzyme I and with the different enzymes II or enzymes III of the PTS, but also with the ATP-dependent HPr kinase, with the P-ser-HPr phosphatase, and with DHA/glycerol kinase.
ISSN:0168-6445
1574-6976
DOI:10.1016/0168-6445(89)90021-1