A succinylanthranilic acid ester and other bioactive constituents of Jolyna laminarioides

• Published in: Phytochemistry (Oxford) 1997-12, Vol.46 (7), p.1215-1218
• Main Authors: Atta-Ur-Rahman, Choudhary, M.Iqbal, Majeed, A., Shabbir, M., Ghani, Usman, Shameel, Mustafa
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents; Anti-Infective Agents - chemistry; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; antimicrobial compounds; aromatic amide; Bacteria - drug effects; Benzaldehydes - chemistry; Benzaldehydes - isolation & purification; Benzaldehydes - pharmacology; Benzoates - chemistry; Benzoates - isolation & purification; Benzoates - pharmacology; Biological and medical sciences; brown alga; Chymotrypsin - antagonists & inhibitors; chymotrypsin inhibition; Escherichia coli - drug effects; Fungi - drug effects; General pharmacology; Jolyna laminarioides; Medical sciences; Microbial Sensitivity Tests; Microsporum - drug effects; Molecular Structure; Phaeophyceae - chemistry; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytol - chemistry; Phytol - isolation & purification; Phytol - pharmacology; Plant Extracts; Protease Inhibitors - chemistry; Protease Inhibitors - isolation & purification; Protease Inhibitors - pharmacology; Scytosiphonaceae; Shigella boydii - drug effects; Stigmasterol - analogs & derivatives; Stigmasterol - chemistry; Stigmasterol - isolation & purification; Stigmasterol - pharmacology
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(97)80014-3

Succinylanthranilic acid ester and three other compounds were isolated for the first time from marine alga Jolyna laminarioides. Compound 1 exhibited chymotrypsin inhibitory and anti-bacterial activities. Methyl 2-[propanamide-2′-methoxycarbonyl]benzoate, fucosterol, trans-phytol and p-formylphenol were isolated for the first time from a methanolic extract of Jolyna laminarioides. Methyl 2-[propanamide-2′-methoxycarbonyl]-benzoate exhibited chymotrypsin inhibitory activity and also found to be active against Escherichia coli and Shigella boydii. Fucosterol exhibited antifungal activity against Curvularia lunata, Stachybotrys atra and Microsporum canis.