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Evaluation of antigens of Fasciola gigantica as vaccines against tropical fasciolosis in cattle
Vaccine trials were conducted in Brahman cross cattle evaluating the efficacy of 4 native antigens purified from adult Fasciola gigantica flukes, and 1 recombinant F. gigantica antigen, as vaccines against tropical fasciolosis. The antigens tested were native glutathione S-transferase, cathepsin L,...
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| Published in: | International journal for parasitology 1997-11, Vol.27 (11), p.1419-1428 |
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| Main Authors: | , , , , , , |
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| container_end_page | 1428 |
| container_issue | 11 |
| container_start_page | 1419 |
| container_title | International journal for parasitology |
| container_volume | 27 |
| creator | Estunningsih, S.Endah Smooker, Peter M. Wiedosari, Ening Widjajanti, Sri Vaiano, Sam Partoutomo, Sutijono Spithill, Terry W. |
| description | Vaccine trials were conducted in Brahman cross cattle evaluating the efficacy of 4 native antigens purified from adult
Fasciola gigantica flukes, and 1 recombinant
F. gigantica antigen, as vaccines against tropical fasciolosis. The antigens tested were native glutathione
S-transferase, cathepsin L, paramyosin, fatty acid binding protein (FABP), and a recombinant FABP expressed in
E. coli, and were formulated in 1 or more of several adjuvants (Quil A, Squalene Montanide 80
®, MF59-100, Auspharm
®, NAGO, polylactoglycolide microspheres, Algammulin, DEAE, Freund's). Vaccination induced low, moderate or high antibody titres to the various antigens which were dependent on the adjuvant. Low but significant reductions in fluke burdens (31%,
P < 0.026) and fluke wet weight (36%,
P < 0.041) were only observed in cattle vaccinated with the native FABP in Freund's adjuvant. There was no correlation between total antibody titres to FABP and protection. The protection observed in cattle vaccinated with native FABP of
F. gigantica supports the notion that this class of proteins is a useful target for protection of animals against
Fasciola and extends the efficacy of FABPs to the tropical liver fluke. This is the first report of vaccination of cattle against
F. gigantica with a purified protein. |
| doi_str_mv | 10.1016/S0020-7519(97)00096-9 |
| format | article |
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Fasciola gigantica flukes, and 1 recombinant
F. gigantica antigen, as vaccines against tropical fasciolosis. The antigens tested were native glutathione
S-transferase, cathepsin L, paramyosin, fatty acid binding protein (FABP), and a recombinant FABP expressed in
E. coli, and were formulated in 1 or more of several adjuvants (Quil A, Squalene Montanide 80
®, MF59-100, Auspharm
®, NAGO, polylactoglycolide microspheres, Algammulin, DEAE, Freund's). Vaccination induced low, moderate or high antibody titres to the various antigens which were dependent on the adjuvant. Low but significant reductions in fluke burdens (31%,
P < 0.026) and fluke wet weight (36%,
P < 0.041) were only observed in cattle vaccinated with the native FABP in Freund's adjuvant. There was no correlation between total antibody titres to FABP and protection. The protection observed in cattle vaccinated with native FABP of
F. gigantica supports the notion that this class of proteins is a useful target for protection of animals against
Fasciola and extends the efficacy of FABPs to the tropical liver fluke. This is the first report of vaccination of cattle against
F. gigantica with a purified protein.</description><identifier>ISSN: 0020-7519</identifier><identifier>EISSN: 1879-0135</identifier><identifier>DOI: 10.1016/S0020-7519(97)00096-9</identifier><identifier>PMID: 9421734</identifier><identifier>CODEN: IJPYBT</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>adjuvant ; Animals ; Antibodies, Helminth - blood ; Antigens, Helminth - therapeutic use ; Biological and medical sciences ; Brahman cattle ; Carrier Proteins - immunology ; Cathepsin L ; Cathepsins - immunology ; Cattle ; Cattle Diseases - prevention & control ; Cysteine Endopeptidases ; Endopeptidases ; Fasciola gigantica ; Fascioliasis - prevention & control ; Fascioliasis - veterinary ; fatty acid binding protein ; Fatty Acid-Binding Protein 7 ; Fatty Acid-Binding Proteins ; Fundamental and applied biological sciences. Psychology ; glutathione S-transferase ; Glutathione Transferase - immunology ; Invertebrates ; Male ; Myelin P2 Protein - immunology ; Nemathelminthia. Plathelmintha ; Neoplasm Proteins ; Nerve Tissue Proteins ; paramyosin ; recombinant antigen ; Tropomyosin - immunology ; vaccine ; Vaccines - therapeutic use ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><ispartof>International journal for parasitology, 1997-11, Vol.27 (11), p.1419-1428</ispartof><rights>1997</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-7894abbb5a9e2700a88171e2047015b1cb6a289e03321f9828adf749de76e5a23</citedby><cites>FETCH-LOGICAL-c515t-7894abbb5a9e2700a88171e2047015b1cb6a289e03321f9828adf749de76e5a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2070069$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9421734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Estunningsih, S.Endah</creatorcontrib><creatorcontrib>Smooker, Peter M.</creatorcontrib><creatorcontrib>Wiedosari, Ening</creatorcontrib><creatorcontrib>Widjajanti, Sri</creatorcontrib><creatorcontrib>Vaiano, Sam</creatorcontrib><creatorcontrib>Partoutomo, Sutijono</creatorcontrib><creatorcontrib>Spithill, Terry W.</creatorcontrib><title>Evaluation of antigens of Fasciola gigantica as vaccines against tropical fasciolosis in cattle</title><title>International journal for parasitology</title><addtitle>Int J Parasitol</addtitle><description>Vaccine trials were conducted in Brahman cross cattle evaluating the efficacy of 4 native antigens purified from adult
Fasciola gigantica flukes, and 1 recombinant
F. gigantica antigen, as vaccines against tropical fasciolosis. The antigens tested were native glutathione
S-transferase, cathepsin L, paramyosin, fatty acid binding protein (FABP), and a recombinant FABP expressed in
E. coli, and were formulated in 1 or more of several adjuvants (Quil A, Squalene Montanide 80
®, MF59-100, Auspharm
®, NAGO, polylactoglycolide microspheres, Algammulin, DEAE, Freund's). Vaccination induced low, moderate or high antibody titres to the various antigens which were dependent on the adjuvant. Low but significant reductions in fluke burdens (31%,
P < 0.026) and fluke wet weight (36%,
P < 0.041) were only observed in cattle vaccinated with the native FABP in Freund's adjuvant. There was no correlation between total antibody titres to FABP and protection. The protection observed in cattle vaccinated with native FABP of
F. gigantica supports the notion that this class of proteins is a useful target for protection of animals against
Fasciola and extends the efficacy of FABPs to the tropical liver fluke. This is the first report of vaccination of cattle against
F. gigantica with a purified protein.</description><subject>adjuvant</subject><subject>Animals</subject><subject>Antibodies, Helminth - blood</subject><subject>Antigens, Helminth - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Brahman cattle</subject><subject>Carrier Proteins - immunology</subject><subject>Cathepsin L</subject><subject>Cathepsins - immunology</subject><subject>Cattle</subject><subject>Cattle Diseases - prevention & control</subject><subject>Cysteine Endopeptidases</subject><subject>Endopeptidases</subject><subject>Fasciola gigantica</subject><subject>Fascioliasis - prevention & control</subject><subject>Fascioliasis - veterinary</subject><subject>fatty acid binding protein</subject><subject>Fatty Acid-Binding Protein 7</subject><subject>Fatty Acid-Binding Proteins</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glutathione S-transferase</subject><subject>Glutathione Transferase - immunology</subject><subject>Invertebrates</subject><subject>Male</subject><subject>Myelin P2 Protein - immunology</subject><subject>Nemathelminthia. Plathelmintha</subject><subject>Neoplasm Proteins</subject><subject>Nerve Tissue Proteins</subject><subject>paramyosin</subject><subject>recombinant antigen</subject><subject>Tropomyosin - immunology</subject><subject>vaccine</subject><subject>Vaccines - therapeutic use</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><issn>0020-7519</issn><issn>1879-0135</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkUuLFDEUhYMoYzv6EwayENFFaZ6VykpkmFFhwIW6DrdSt5pIddIm6Qb_vanpprezSsj57iPnEHLD2UfOeP_pJ2OCdUZz-96aD4wx23f2GdnwwdiOcamfk80FeUlelfKHMa6lUlfkyirBjVQb4u6OsByghhRpminEGrYYy3q_h-JDWoBuw3Z990Ch0CN4HyIWClsIsVRac9o3baHziU8lFBoi9VDrgq_JixmWgm_O5zX5fX_36_Zb9_Dj6_fbLw-d11zXzgxWwTiOGiwKwxgMAzccBVOm7TxyP_YgBotMSsFnO4gBptkoO6HpUYOQ1-Tdqe8-p78HLNXtQvG4LBAxHYozVnMu1dMg76XoZa8aqE-gz6mUjLPb57CD_M9x5tYE3GMCbrXXWeMeE3C21d2cBxzGHU6XqrPlTX971ptfsMwZog_lggnWvt-vbT6fMGyuHQNm19zF6HEKGX11UwpPLPIfO6CiCw</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>Estunningsih, S.Endah</creator><creator>Smooker, Peter M.</creator><creator>Wiedosari, Ening</creator><creator>Widjajanti, Sri</creator><creator>Vaiano, Sam</creator><creator>Partoutomo, Sutijono</creator><creator>Spithill, Terry W.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19971101</creationdate><title>Evaluation of antigens of Fasciola gigantica as vaccines against tropical fasciolosis in cattle</title><author>Estunningsih, S.Endah ; Smooker, Peter M. ; Wiedosari, Ening ; Widjajanti, Sri ; Vaiano, Sam ; Partoutomo, Sutijono ; Spithill, Terry W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-7894abbb5a9e2700a88171e2047015b1cb6a289e03321f9828adf749de76e5a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>adjuvant</topic><topic>Animals</topic><topic>Antibodies, Helminth - blood</topic><topic>Antigens, Helminth - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Brahman cattle</topic><topic>Carrier Proteins - immunology</topic><topic>Cathepsin L</topic><topic>Cathepsins - immunology</topic><topic>Cattle</topic><topic>Cattle Diseases - prevention & control</topic><topic>Cysteine Endopeptidases</topic><topic>Endopeptidases</topic><topic>Fasciola gigantica</topic><topic>Fascioliasis - prevention & control</topic><topic>Fascioliasis - veterinary</topic><topic>fatty acid binding protein</topic><topic>Fatty Acid-Binding Protein 7</topic><topic>Fatty Acid-Binding Proteins</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>glutathione S-transferase</topic><topic>Glutathione Transferase - immunology</topic><topic>Invertebrates</topic><topic>Male</topic><topic>Myelin P2 Protein - immunology</topic><topic>Nemathelminthia. Plathelmintha</topic><topic>Neoplasm Proteins</topic><topic>Nerve Tissue Proteins</topic><topic>paramyosin</topic><topic>recombinant antigen</topic><topic>Tropomyosin - immunology</topic><topic>vaccine</topic><topic>Vaccines - therapeutic use</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Estunningsih, S.Endah</creatorcontrib><creatorcontrib>Smooker, Peter M.</creatorcontrib><creatorcontrib>Wiedosari, Ening</creatorcontrib><creatorcontrib>Widjajanti, Sri</creatorcontrib><creatorcontrib>Vaiano, Sam</creatorcontrib><creatorcontrib>Partoutomo, Sutijono</creatorcontrib><creatorcontrib>Spithill, Terry W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal for parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Estunningsih, S.Endah</au><au>Smooker, Peter M.</au><au>Wiedosari, Ening</au><au>Widjajanti, Sri</au><au>Vaiano, Sam</au><au>Partoutomo, Sutijono</au><au>Spithill, Terry W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of antigens of Fasciola gigantica as vaccines against tropical fasciolosis in cattle</atitle><jtitle>International journal for parasitology</jtitle><addtitle>Int J Parasitol</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>27</volume><issue>11</issue><spage>1419</spage><epage>1428</epage><pages>1419-1428</pages><issn>0020-7519</issn><eissn>1879-0135</eissn><coden>IJPYBT</coden><abstract>Vaccine trials were conducted in Brahman cross cattle evaluating the efficacy of 4 native antigens purified from adult
Fasciola gigantica flukes, and 1 recombinant
F. gigantica antigen, as vaccines against tropical fasciolosis. The antigens tested were native glutathione
S-transferase, cathepsin L, paramyosin, fatty acid binding protein (FABP), and a recombinant FABP expressed in
E. coli, and were formulated in 1 or more of several adjuvants (Quil A, Squalene Montanide 80
®, MF59-100, Auspharm
®, NAGO, polylactoglycolide microspheres, Algammulin, DEAE, Freund's). Vaccination induced low, moderate or high antibody titres to the various antigens which were dependent on the adjuvant. Low but significant reductions in fluke burdens (31%,
P < 0.026) and fluke wet weight (36%,
P < 0.041) were only observed in cattle vaccinated with the native FABP in Freund's adjuvant. There was no correlation between total antibody titres to FABP and protection. The protection observed in cattle vaccinated with native FABP of
F. gigantica supports the notion that this class of proteins is a useful target for protection of animals against
Fasciola and extends the efficacy of FABPs to the tropical liver fluke. This is the first report of vaccination of cattle against
F. gigantica with a purified protein.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9421734</pmid><doi>10.1016/S0020-7519(97)00096-9</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | International journal for parasitology, 1997-11, Vol.27 (11), p.1419-1428 |
| issn | 0020-7519 1879-0135 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79511342 |
| source | Elsevier |
| subjects | adjuvant Animals Antibodies, Helminth - blood Antigens, Helminth - therapeutic use Biological and medical sciences Brahman cattle Carrier Proteins - immunology Cathepsin L Cathepsins - immunology Cattle Cattle Diseases - prevention & control Cysteine Endopeptidases Endopeptidases Fasciola gigantica Fascioliasis - prevention & control Fascioliasis - veterinary fatty acid binding protein Fatty Acid-Binding Protein 7 Fatty Acid-Binding Proteins Fundamental and applied biological sciences. Psychology glutathione S-transferase Glutathione Transferase - immunology Invertebrates Male Myelin P2 Protein - immunology Nemathelminthia. Plathelmintha Neoplasm Proteins Nerve Tissue Proteins paramyosin recombinant antigen Tropomyosin - immunology vaccine Vaccines - therapeutic use Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies |
| title | Evaluation of antigens of Fasciola gigantica as vaccines against tropical fasciolosis in cattle |
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