Adenovirus-induced liver necrosis in a case of AIDS

Adenovirus-induced liver necrosis is rare. Because the era of AIDS (acquired immunodeficiency syndrome) this entity was seen predominantly in infants suffering from inborn immunodeficiency syndromes or from iatrogenic immunosuppression because of bone marrow or liver transplantation. Here, we report...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 1997-12, Vol.431 (6), p.469-472
Main Authors: DOMBROWSKI, F, EIS-HÜBINGER, A.-M, ACKERMANN, T, BLÜMEL, J, SPENGLER, U, PFEIFER, U
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - complications
Adenoviridae - ultrastructure
Adenoviridae Infections - complications
Adenoviridae Infections - pathology
Adult
AIDS/HIV
Biological and medical sciences
Biopsy, Needle
Fatal Outcome
Female
Gastroenterology. Liver. Pancreas. Abdomen
Human viral diseases
Humans
Infectious diseases
Liver - pathology
Liver - ultrastructure
Liver - virology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Microscopy, Electron
Necrosis
Other diseases. Semiology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Adenovirus-induced liver necrosis is rare. Because the era of AIDS (acquired immunodeficiency syndrome) this entity was seen predominantly in infants suffering from inborn immunodeficiency syndromes or from iatrogenic immunosuppression because of bone marrow or liver transplantation. Here, we report a case of a 30-year-old woman with AIDS who developed fever and rapidly progressing liver failure. A frozen section from a needle biopsy of the liver allowed a quick diagnosis of viral liver necrosis. The light-microscopic and electron microscopic aspects were typical of adenovirus infection and should be known to the surgical pathologist. The diagnosis was confirmed by immunohistochemistry and DNA hybridization analysis.
ISSN:0945-6317
1432-2307
DOI:10.1007/s004280050125