Evaluation of maternal plasma creatine kinase activity as a marker of abnormal early pregnancy

We have tested the value of maternal plasma creatine kinase activity for diagnosing ectopic pregnancies obtained after in-vitro fertilization and embryo transfer. Plasma creatine kinase was assayed in 57 patients: 20 normal, 23 miscarriages and 14 ectopic pregnancies, for a total of 240 samples. All...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1997-11, Vol.12 (11), p.2534-2537
Main Authors: Zorn, Jean-René, Cherruau, Brigitte, Abi-Rached, Fady, Dehée, Axelle, Danoy, Xavier, Le Blond, Josiane, Ekindjian, Ohvanesse
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers
creatine kinase
Creatine Kinase - blood
Diseases of mother, fetus and pregnancy
ectopic pregnancy
Female
Gynecology. Andrology. Obstetrics
Humans
in-vitro fertilization
Medical sciences
Predictive Value of Tests
Pregnancy - blood
Pregnancy Complications - blood
Pregnancy Outcome
Pregnancy. Fetus. Placenta
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Summary:We have tested the value of maternal plasma creatine kinase activity for diagnosing ectopic pregnancies obtained after in-vitro fertilization and embryo transfer. Plasma creatine kinase was assayed in 57 patients: 20 normal, 23 miscarriages and 14 ectopic pregnancies, for a total of 240 samples. All values were in the lower part of the normal range except only one in a miscarrying patient. A statistically significant difference was observed for a cut-off value of 45 IU/l between normal and ectopic pregnancies. However, for this cut-off point, the measurement of plasma creatine kinase activity had a sensitivity of 0.50 and a specificity of 0.76 for the diagnosis of ectopic pregnancy. The positive predictive value was 0.69. Creatine kinase activity measurements are thus of no practical value in this particular population, in which an early and specific marker of ectopic implantation would be of paramount interest. The association of human chorionic gonadotrophin (HCG) determinations and ultrasound scanning of the pelvis still remain the best paraclinical support for an early diagnosis of ectopic implantation.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/12.11.2534