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Expression of glucose transporter and glucose uptake in human oocytes and preimplantation embryos

The expression of glucose transporters 1, 2, 3 and 4 was evaluated in human oocytes and polyploid preimplantation embryos. Only glucose transporter 1 (GLUT-1) isoform was detected in oocytes and in 2–12-cell stage embryos. Glucose uptake was markedly increased in embryos as compared to oocytes (19.7...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1997-11, Vol.12 (11), p.2508-2510
Main Authors: Dan-Goor, Mary, Sasson, Shlomo, Davarashvili, Anna, Almagor, Miriam
Format: Article
Language:English
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Summary:The expression of glucose transporters 1, 2, 3 and 4 was evaluated in human oocytes and polyploid preimplantation embryos. Only glucose transporter 1 (GLUT-1) isoform was detected in oocytes and in 2–12-cell stage embryos. Glucose uptake was markedly increased in embryos as compared to oocytes (19.7 ± 3.4 pmol/min/embryo and 2.3 ± 0.3 pmol/min/oocyte), and GLUT-1 was inhibited by cytochalasin B. These results suggest that, although GLUT-1 is expressed in human oocytes and throughout preimplantation development, its function in mediating the rise in glucose uptake is triggered following fertilization.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/12.11.2508