Lack of endogenous estrogens effects on circulating adhesion molecule ICAM-1

The serum vascular adhesion molecule ICAM-1 that is involved in atherogenesis was determined in fertile, postmenopausal and at term pregnant women. The aim of the study was to ascertain if the antiatherogenic estrogens action may involve this adhesion molecule. The serum ICAM-1 concentrations result...

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Bibliographic Details
Published in:Journal of endocrinological investigation 1997-11, Vol.20 (10), p.621-622
Main Authors: JASONNI, V. M, BUEMI, M, D'ANNA, R, ALLEGRA, A, RUELLO, A, SCILIPOTI, A, LEONARDI, J
Format: Article
Language:English
Subjects:
Adult
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Estrogens - physiology
Female
Humans
Intercellular Adhesion Molecule-1 - blood
Labor, Obstetric - physiology
Medical sciences
Middle Aged
Postmenopause - physiology
Pregnancy
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Summary:The serum vascular adhesion molecule ICAM-1 that is involved in atherogenesis was determined in fertile, postmenopausal and at term pregnant women. The aim of the study was to ascertain if the antiatherogenic estrogens action may involve this adhesion molecule. The serum ICAM-1 concentrations resulted similar in the three groups studied: 331 +/- 35 ng/ml, 333 +/- 28 ng/ml and 302 +/- 53 ng/ml in fertile, postmenopausal and pregnant subjects respectively, despite the very different estrogen plasma levels. These data, the first on the ICAM-1 serum levels in women with different natural hormonal milieu, demonstrate that estrogens antiatherogenic action is not involving ICAM-1.
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03346920