Defect in Th1-Like Cells of Nonresponders to Hepatitis B Vaccine

Peripheral blood lymphocytes from nonresponders to hepatitis B vaccine (HBsAg) failed to undergo a proliferative response to recombinant HBsAg in vitro, whereas cells from responders proliferated vigorously. The lack of proliferative response was not due to defective antigen presentation in that MHC...

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Bibliographic Details
Published in:Human immunology 1997-11, Vol.58 (1), p.42-51
Main Authors: Chedid, Marie G, Deulofeut, Harold, Yunis, David E, Lara-Marquez, Maria Luz, Salazar, Marcela, Deulofeut, Richard, Awdeh, Zuheir, Alper, Chester A, Yunis, Edmond J
Format: Article
Language:English
Subjects:
Adult
Aged
AIDS/HIV
Cells, Cultured
Hepatitis B Surface Antigens - immunology
Hepatitis B Vaccines - immunology
Humans
Interleukin-2 - immunology
Interleukin-2 - pharmacology
Middle Aged
Phytohemagglutinins - immunology
Tetanus Toxoid - immunology
Th1 Cells - immunology
Vaccines, Synthetic - immunology
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Summary:Peripheral blood lymphocytes from nonresponders to hepatitis B vaccine (HBsAg) failed to undergo a proliferative response to recombinant HBsAg in vitro, whereas cells from responders proliferated vigorously. The lack of proliferative response was not due to defective antigen presentation in that MHC-identical responder and nonresponder antigen presenting cells were equally effective in stimulating responder T cells. Nonresponder T cells did not proliferate in response to antigen-pulsed MHC identical responder antigen presenting cells. The present study demonstrated that: 1) there were no detectable (1 in
ISSN:0198-8859
1879-1166
DOI:10.1016/S0198-8859(97)00209-7