Lack of correlation of anaemia with splenomegaly and hepatomegaly in Trypanosoma brucei and Trypanosoma congolense infections of rats

Isolates of Trypanosoma brucei and Trypanosoma congolense from the blood of cattle were used to infect growing rats. Despite the use of similar infective doses, T. brucei parasitaemia appeared earlier than T. congolense parasitaemia. After the same period of parasitaemia, the degrees of anaemia, spl...

Full description

Saved in:
Bibliographic Details
Published in:Journal of comparative pathology 1997-10, Vol.117 (3), p.261-265
Main Authors: Igbokwe, I.O., Nwosu, C.O.
Format: Article
Language:English
Subjects:
Anemia - parasitology
Anemia - physiopathology
Anemia - veterinary
Animals
Cattle
Female
Hepatomegaly - blood
Hepatomegaly - parasitology
Hepatomegaly - veterinary
Parasitemia - blood
Parasitemia - physiopathology
Parasitemia - veterinary
Rats
Splenomegaly - blood
Splenomegaly - parasitology
Splenomegaly - veterinary
Trypanosoma brucei brucei
Trypanosoma congolense
Trypanosomiasis, African - blood
Trypanosomiasis, African - physiopathology
Trypanosomiasis, African - veterinary
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Isolates of Trypanosoma brucei and Trypanosoma congolense from the blood of cattle were used to infect growing rats. Despite the use of similar infective doses, T. brucei parasitaemia appeared earlier than T. congolense parasitaemia. After the same period of parasitaemia, the degrees of anaemia, splenomegaly and hepatomegaly were similar in both infections. The percentage decrease in packed cell volume was not correlated with splenic and hepatic weights. Neither infection significantly affected the weight gain of the rats. It was concluded that both organisms caused diseases of comparable severity and that the mere enlargement of the spleen and liver made no significant contribution to the development of the anaemia.
ISSN:0021-9975
1532-3129
DOI:10.1016/S0021-9975(97)80020-5