The effect of the OmpT protease on excision repair in UV-irradiated Escherichia coli

The extent of pyrimidine dimer excision (PDE) was inhibited in UV-irradiated E. coli KS272 ( ompT′) cells when they were preinduced by a low UV predose preceeded by a nutrition stress but not in the preinduced E. coli SF100 ( ompT) mutants. The preinduction, however, markedly inhibited PDE in the om...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 1997-12, Vol.41 (3), p.245-248
Main Authors: Sedliaková, M, Masek, F, Slezáriková, V, Pirsel, M
Format: Article
Language:English
Subjects:
DNA Damage
DNA Repair
DNA, Bacterial - radiation effects
E. coli
Escherichia coli - genetics
Escherichia coli - radiation effects
Gene Deletion
ompT gene
Serine Endopeptidases - genetics
Serine Endopeptidases - metabolism
Stress conditions
Ultraviolet Rays
UV irradiation
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Summary:The extent of pyrimidine dimer excision (PDE) was inhibited in UV-irradiated E. coli KS272 ( ompT′) cells when they were preinduced by a low UV predose preceeded by a nutrition stress but not in the preinduced E. coli SF100 ( ompT) mutants. The preinduction, however, markedly inhibited PDE in the ompT cells transformed with a multicopy plasmid carrying ompT gene. The data are consistent with the hypothesis that the inducible OmpT protease (controlled by rpoH) might terminate the SOS period of excision repair so that when cells are preinduced PDE might be inhibited prematurely.
ISSN:1011-1344
1873-2682
DOI:10.1016/S1011-1344(97)00111-5