Rapid changes in brainstem maps of adult primates after peripheral injury

Cerebral cortical maps in adult primates reorganize within minutes-hours after peripheral injuries, but subcortical versus intracortical contributions to this rapid reorganization remain controversial. The present results show that injury of nerves to the hands of adult monkeys triggers rapid (minut...

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Bibliographic Details
Published in:Brain research 1997-11, Vol.774 (1), p.211-215
Main Authors: Xu, J, Wall, J.T
Format: Article
Language:English
Subjects:
Animals
Brain Mapping
Brain Stem - physiopathology
Brainstem mapping
Callithrix - physiology
Cortex
Denervation
Hand - innervation
Nerve injury
Neuronal Plasticity - physiology
Peripheral Nerve Injuries
Primate cuneate nucleus
Saimiri - physiology
Somatosensory plasticity
Time Factors
Wounds and Injuries - physiopathology
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Summary:Cerebral cortical maps in adult primates reorganize within minutes-hours after peripheral injuries, but subcortical versus intracortical contributions to this rapid reorganization remain controversial. The present results show that injury of nerves to the hands of adult monkeys triggers rapid (minutes–hours) changes in maps of the hand in the brainstem main cuneate nucleus. These findings suggest that peripheral injury causes an initial concurrent reorganization of brainstem and cortical substrates and that early sensory changes emerge from reorganization involving multiple central levels.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(97)81706-4