Emergence of Ciprofloxacin-Resistant Coagulase-Negative Staphylococcal Skin Flora in Immunocompromised Patients Receiving Ciprofloxacin

Seven septicemias in neutropenic leukemia patients (two with fatal outcome) caused by ciprofloxacin-resistant coagulase-negative staphylococci were diagnosed in the hematologic unit of Turku University Central Hospital in 1988soon after the introduction of the drug. Coagulasenegative staphylococcal...

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Bibliographic Details
Published in:The Journal of infectious diseases 1990-01, Vol.161 (1), p.41-44
Main Authors: Kotilainen, Pirkko, Nikoskelainen, Jukka, Huovinen, Pentti
Format: Article
Language:English
Subjects:
Aged
Bacteriology
Biological and medical sciences
Blood
Ciprofloxacin - pharmacology
Coagulase - metabolism
Drug Resistance, Microbial - genetics
Female
Flora
Fluoroquinolones
Fundamental and applied biological sciences. Psychology
Genetics
Humans
Immune Tolerance
Infections
Leukemia
Leukemia, Myeloid, Acute - complications
Leukemia, Myeloid, Acute - immunology
Major Articles
Male
Microbial Sensitivity Tests
Microbiology
Middle Aged
Multiple Myeloma - complications
Multiple Myeloma - immunology
Neutropenia
Neutropenia - complications
Neutropenia - immunology
Plasmids
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
R Factors
Sepsis
Sepsis - drug therapy
Sepsis - etiology
Skin
Skin - microbiology
Staphylococcus
Staphylococcus - drug effects
Staphylococcus - genetics
Staphylococcus - metabolism
Staphylococcus epidermidis - drug effects
Staphylococcus epidermidis - genetics
Staphylococcus epidermidis - isolation & purification
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Description
Summary:Seven septicemias in neutropenic leukemia patients (two with fatal outcome) caused by ciprofloxacin-resistant coagulase-negative staphylococci were diagnosed in the hematologic unit of Turku University Central Hospital in 1988soon after the introduction of the drug. Coagulasenegative staphylococcal skin flora of 28 neutropenic patients receiving ciprofloxacin prophylaxis and therapy for gram-negative bacterial infections were compared with those of 31 untreated patients and 33 hospital personnel working in the same unit. In ciprofloxacin-treated patients the flora were almost completely ciprofloxacin-resistant, whereas in the control groups resistant flora were detected only occasionally. Similarities in the plasmid profile patterns were found in 91%of the ciprofloxacin-resistant coagulase-negative staphylococci, suggesting an epidemiologic relation between these strains. It seems evident that cross-infection is responsible for the spread of ciprofloxacin-resistant coagulase-negative staphylococci in these patients.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/161.1.41