Does a moderate hypoxia induce manganese-superoxide dismutase or heat shock proteins to act as possible protective factors?

Male Wistar rats were kept in a hypoxia chamber (9% O2) for eight hours. Control animals breathed room air in the same chamber for a similar period of time. One week later the brains of all rats were prepared for the immunohistochemical demonstration of Mn-superoxide dismutase (Mn-SOD). In compariso...

Full description

Saved in:
Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1997-12, Vol.356 (6), p.746-749
Main Authors: Pohle, W, Rauca, C
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Enzyme Induction
Heat-Shock Proteins - biosynthesis
Hypoxia - metabolism
Immunohistochemistry
Male
Rats
Rats, Wistar
Superoxide Dismutase - biosynthesis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Male Wistar rats were kept in a hypoxia chamber (9% O2) for eight hours. Control animals breathed room air in the same chamber for a similar period of time. One week later the brains of all rats were prepared for the immunohistochemical demonstration of Mn-superoxide dismutase (Mn-SOD). In comparison with the sham-exposed controls, the hypoxia-treated animals showed an increase in the number of Mn-SOD-immunoreactive neurons in several hippocampal structures. The 72 kD heat shock protein was not found to be induced one week after a moderate hypoxia.
ISSN:0028-1298
DOI:10.1007/PL00005113