Reduction of intrapulmonary shunt and resolution of digital clubbing associated with primary biliary cirrhosis after liver transplantation

This report describes a patient with marked hypoxemia caused by intrapulmonary shunt associated with primary biliary cirrhosis. Liver transplantation resulted in resolution of digital clubbing and reduction of intrapulmonary shunt as demonstrated by normalization of room air arterial blood gases, re...

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Bibliographic Details
Published in:Hepatology (Baltimore, Md.) Md.), 1990-01, Vol.11 (1), p.54-58
Main Authors: Stoller, James K., Moodie, Douglas, Schiavone, William A., Vogt, David, Broughan, Thomas, Winkelman, Eugene, Rehm, Patrice K., Carey, William D.
Format: Article
Language:English
Subjects:
Adult
Arteriovenous Fistula - surgery
Biological and medical sciences
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hypoxia - etiology
Hypoxia - surgery
Liver Cirrhosis, Biliary - complications
Liver Cirrhosis, Biliary - surgery
Liver Transplantation
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Osteoarthropathy, Secondary Hypertrophic - etiology
Osteoarthropathy, Secondary Hypertrophic - surgery
Other diseases. Semiology
Pulmonary Artery
Pulmonary Circulation
Pulmonary Veins
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Summary:This report describes a patient with marked hypoxemia caused by intrapulmonary shunt associated with primary biliary cirrhosis. Liver transplantation resulted in resolution of digital clubbing and reduction of intrapulmonary shunt as demonstrated by normalization of room air arterial blood gases, reduction in shunt fraction and normalization of the indocyanin‐enhanced echocardiogram and perfusion lung scan. This patient's course challenges the conventional notion that intrapulmonary shunting associated with chronic liver disease does not reverse after liver transplantation. (HEPATOLOGY 1990; 11: 54–58.)
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840110111