An evaluation of CA125 levels in 291 normal postmenopausal and 20 endometrial adenocarcinoma-bearing women before and after surgery

Two hundred ninety-one normal postmenopausal women without hormone replacement therapy were studied for their blood levels of CA125. The levels ranged from 0.1 to 31.8 U/ml (mean±SEM 5.5±0.3 U/ml). Twenty patients with endometrial adenocarcinoma who had preoperative CA125 levels below 50 U/ml were a...

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Published in:Cancer letters 1997-12, Vol.121 (1), p.69-72
Main Authors: Takami, Masashi, Sakamoto, Hideki, Ohtani, Kaori, Takami, Takeshi, Satoh, Kazuo
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - blood
CA-125 Antigen - blood
CA125
Endometrial adenocarcinoma
Endometrial Neoplasms - blood
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Middle Aged
Postmenopausal women
Postmenopause
Postoperative Period
Tumors
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container_title Cancer letters
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creator Takami, Masashi
Sakamoto, Hideki
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description Two hundred ninety-one normal postmenopausal women without hormone replacement therapy were studied for their blood levels of CA125. The levels ranged from 0.1 to 31.8 U/ml (mean±SEM 5.5±0.3 U/ml). Twenty patients with endometrial adenocarcinoma who had preoperative CA125 levels below 50 U/ml were also studied. The levels of CA125 in the latter group ranged from 2.1 to 43.0 U/ml (17.2±2.3 U/ml) and the difference of the mean value of the two groups was statistically significant ( P
doi_str_mv 10.1016/S0304-3835(97)00332-7
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The levels ranged from 0.1 to 31.8 U/ml (mean±SEM 5.5±0.3 U/ml). Twenty patients with endometrial adenocarcinoma who had preoperative CA125 levels below 50 U/ml were also studied. The levels of CA125 in the latter group ranged from 2.1 to 43.0 U/ml (17.2±2.3 U/ml) and the difference of the mean value of the two groups was statistically significant ( P&lt;0.001). The CA125 levels in normal postmenopausal women have a weak negative correlation with their age (CA125=−0.025×age+6.9, P&lt;0.001), whereas in cancer patients, a positive correlation was seen (CA125=0.6×age+11.5, P&lt;0.05). Patients with endometrial cancer showed a decrease in their CA125 levels after a hysterectomy and salpingo-oophorectomy (6.5±1.2 U/ml, P&lt;0.0001). These results confirmed that the normal range of the CA125 of menopausal women is much lower than that of cycling women and each laboratory should establish its own normal range for the population. 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1872-7980
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subjects Adenocarcinoma - blood
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - blood
CA-125 Antigen - blood
CA125
Endometrial adenocarcinoma
Endometrial Neoplasms - blood
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Middle Aged
Postmenopausal women
Postmenopause
Postoperative Period
Tumors
title An evaluation of CA125 levels in 291 normal postmenopausal and 20 endometrial adenocarcinoma-bearing women before and after surgery
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