Proaggregatory and procoagulant properties of three murine mammary gland tumor cell lines with different metastatic capabilities

We have investigated the in vitro proaggregatory and procoagulant properties of three murine tumor cell lines having different metastatic potentials. The characterization was carried out with appropiate procoagulant inhibitors and plasma deficient in factors VII and X. The proaggregatory properties...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1997-12, Vol.49 (5), p.403-407
Main Authors: Pasqualini, M.E., Moreno, L. Ruiz, Muñoz, S.E., Eynard, A.R.
Format: Article
Language:English
Subjects:
Adenocarcinoma - blood
Adenocarcinoma - pathology
Animals
Biological and medical sciences
Blood Coagulation
Blood Coagulation Tests
Cysteine Endopeptidases - blood
Dissemination
Female
Mammary gland, tumor cells
Mammary Neoplasms, Experimental - blood
Mammary Neoplasms, Experimental - pathology
Medical sciences
Metastatic capabilities, mammary tumors
Mice
Mice, Inbred BALB C
Neoplasm Metastasis - pathology
Neoplasm Proteins
Platelet Aggregation
Platelet Count
Proaggregation
Procoagulation
Tropical medicine
Tumor cell
Tumor cell lines, Mammary gland
Tumor Cells, Cultured
Tumors
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Summary:We have investigated the in vitro proaggregatory and procoagulant properties of three murine tumor cell lines having different metastatic potentials. The characterization was carried out with appropiate procoagulant inhibitors and plasma deficient in factors VII and X. The proaggregatory properties of M2, M3 and MM3 cell lines increased according to their metastatic potentials. Their procoagulant activity were dependent on factor X. The prothrombotic abilities exhibited by neoplastic cells (NC), acting synergistically, might play a role in cancer dissemination.
ISSN:0940-2993
1618-1433
DOI:10.1016/S0940-2993(97)80127-3