Pattern electroretinogram recorded by skin electrodes in early ocular hypertension and glaucoma

Diagnostic value of transient pattern electroretinogram (PERG), recorded by skin electrodes, was compared with Goldmann perimetry in cases of ocular hypertension and glaucoma. According to the assumption that the PERG mostly reflects activity of the retinal ganglion cells, and histological evidence...

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Bibliographic Details
Published in:Documenta ophthalmologica 1989-10, Vol.73 (2), p.183-191
Main Authors: HAWLINA, M, STRUCL, M, STIRN-KRANJC, B, FINDERLE, Z, BRECELJ, J
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Electroretinography
Female
Form Perception
Galvanic Skin Response
Glaucoma and intraocular pressure
Glaucoma, Open-Angle - diagnosis
Humans
Intraocular Pressure
Male
Medical sciences
Middle Aged
Ocular Hypertension - diagnosis
Ophthalmology
Pattern Recognition, Visual
Predictive Value of Tests
Visual Acuity
Visual Field Tests
Visual Fields
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Summary:Diagnostic value of transient pattern electroretinogram (PERG), recorded by skin electrodes, was compared with Goldmann perimetry in cases of ocular hypertension and glaucoma. According to the assumption that the PERG mostly reflects activity of the retinal ganglion cells, and histological evidence that 30-50% atrophy of the retinal ganglion cells is necessary to cause defects in visual field, we wanted to assess if i) this method could be more sensitive in detecting early glaucomatous damage than routine Goldmann perimetry in eyes with normal or only borderline elevated intraocular pressure in the time of PERG recording (first group of patients), and ii) how the PERG amplitude corresponds to ganglion cell loss, expected in the eyes with already detectable initial glaucomatous visual field defects, according to Goldmann II/2 isopter, with normal or borderline elevated intraocular pressure in the time of PERG recording (second group). In the group with no visual field defects subnormal amplitude of the major positive component of the PERG, N1-P1, was detected in three of 30 eyes (10%), while in the group with initial visual field defects N1-P1 amplitude was subnormal in 6 of 11 eyes (54%). The amplitude of the major negative PERG component, P1-N2, was found normal in all eyes of the first group and subnormal in 5 eyes (45%) of the second group.
ISSN:0012-4486
1573-2622
DOI:10.1007/BF00155036