EFFECT OF GANGLIOSIDE GM1 ON ETHANOL-INDUCED CHANGES IN THE INCORPORATION OF FREE FATTY ACIDS INTO MEMBRANE PHOSPHOLIPIDS IN MOUSE BRAIN

Our previous studies with mice showed that chronic ethanol (EtOH) administration affected the incorporation of unsaturated free fatty acids (FFA) into four major brain phospholipids (PL). In the current study, we investigated the effects of ganglioside GM1 pretreatment on EtOH-induced changes in the...

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Published in:Alcohol and alcoholism (Oxford) 1997-11, Vol.32 (6), p.693-701
Main Authors: ZHENG, ZHIHONG, BARKAI, AMIRAM I., HUNGUND, BASALINGAPPA L.
Format: Article
Language:English
Subjects:
Alcoholism and acute alcohol poisoning
Animals
Biological and medical sciences
Brain Chemistry - drug effects
Central Nervous System Depressants - pharmacology
Docosahexaenoic Acids - metabolism
Ethanol - pharmacology
Fatty Acids, Nonesterified - metabolism
G(M1) Ganglioside - pharmacology
In Vitro Techniques
Male
Medical sciences
Membranes - drug effects
Membranes - metabolism
Mice
Neuroprotective Agents - pharmacology
Phospholipids - metabolism
Synaptosomes - drug effects
Synaptosomes - metabolism
Synaptosomes - ultrastructure
Toxicology
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Summary:Our previous studies with mice showed that chronic ethanol (EtOH) administration affected the incorporation of unsaturated free fatty acids (FFA) into four major brain phospholipids (PL). In the current study, we investigated the effects of ganglioside GM1 pretreatment on EtOH-induced changes in the incorporation of various FFA into cerebral PL in mice. Consistent with our earlier findings, the results suggest that chronic EtOH exposure alters the incorporation of unsaturated fatty acids into phosphatidylinositol (PI), phosphatidylserine, and phosphatidylcholine (PC), but not into phosphatidyl-ethanolamine (PE). No significant differences were observed with stearic acid. The ganglioside GM1 treatment led to increased incorporation of linoleic acid (LA) into PE and PC and appeared to enhance the EtOH-produced effects especially for docosahexaenoic acid (DHA) and to a lesser extent for oleic acid, LA, and arachidonic acid, when compared to the untreated control group. However, when comparison was made with the EtOH-alone group, significant differences were observed only with DHA incorporation and mainly into PE and PI. Thus acyltransferases may play an important role in membrane adaptation to the injurious effects of EtOH and GM1 appears to enhance selective incorporation of FFA into membrane PL; a process that may represent a repair mechanism.
ISSN:0735-0414
1464-3502
DOI:10.1093/oxfordjournals.alcalc.a008319