Carotid blood flow changes with behavioral states in the late gestation llama fetus in utero

This study tested the hypothesis that in the llama fetus changes in cerebral blood flow are closely associated with changes in cerebral oxidative metabolism such as occur during transitions between electrocortical states. For the first time reported in any species, instantaneous changes in common ca...

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Bibliographic Details
Published in:Brain research. Developmental brain research 1997-12, Vol.104 (1), p.137-141
Main Authors: Blanco, C.E, Giussani, D.A, Riquelme, R.A, Hanson, M.A, Llanos, A.J
Format: Article
Language:English
Subjects:
Altitude
Animals
Behavior, Animal - physiology
Behavioral state
Camelids, New World - embryology
Camelids, New World - physiology
Carotid Arteries - physiology
Cerebral blood flow
Cerebral oxygen consumption
Cerebrovascular Circulation - physiology
ECoG
Electroencephalography
Embryonic and Fetal Development - physiology
Gestational Age
Hypoxia
Llama fetus
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Summary:This study tested the hypothesis that in the llama fetus changes in cerebral blood flow are closely associated with changes in cerebral oxidative metabolism such as occur during transitions between electrocortical states. For the first time reported in any species, instantaneous changes in common carotid blood flow, employed as a continuous index of cerebrovascular perfusion, were related to instantaneous changes in electrocortical activity. Three late gestation fetal llamas were surgically prepared under general anesthesia with vascular catheters, a tracheal and amniotic catheter, and with electrodes implanted to monitor the fetal electrocorticogram (ECoG). In addition, Transonic flow probes were placed around a common carotid artery and a femoral artery. At least 4 days after surgery fetal arterial blood, amniotic and tracheal pressures, carotid and femoral blood flows and the fetal ECoG were recorded continuously. Our results suggest a close association between increases in common carotid blood flow and low voltage ECoG in the llama fetus. Close coupling between instantaneous changes in carotid blood flow and electrocortical states together with the lack of an increase in brain blood flow without increased cerebral oxygen extraction during hypoxemia in the llama fetus supports a fall in cerebral oxidative metabolism in this species during hypoxemic episodes.
ISSN:0165-3806
DOI:10.1016/S0165-3806(97)00174-0