Enhanced clearance of vancomycin by hemodialysis in a child

Clearance of vancomycin by hemodialysis has previously been reported to be negligible. We describe a child undergoing chronic hemodialysis using a hollow fiber dialyzer with cellulose acetate membrane. When the patient was treated with intravenous vancomycin for staphylococcal bacteremia, the serum...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 1989-01, Vol.3 (1), p.83-85
Main Authors: SCHOUMACHER, R, CHEVALIER, R. L, GOMEZ, R. A, ROGOL, A. D, CUMMINGS, R, SPYKER, D. A
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Child
Female
Half-Life
Humans
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - therapy
Medical sciences
Pharmacology. Drug treatments
Renal Dialysis
Vancomycin - pharmacokinetics
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Summary:Clearance of vancomycin by hemodialysis has previously been reported to be negligible. We describe a child undergoing chronic hemodialysis using a hollow fiber dialyzer with cellulose acetate membrane. When the patient was treated with intravenous vancomycin for staphylococcal bacteremia, the serum vancomycin half-life was found to decrease by more than 90% during each course of hemodialysis. We conclude that, contrary to prevailing opinion, vancomycin can be rapidly cleared by hemodialysis in the small pediatric patient, and that the dosage should be adjusted accordingly.
ISSN:0931-041X
1432-198X
DOI:10.1007/BF00859632