Changes in auditory P300 in patients with major depression and silent cerebral infarction

We examined event-related potentials in patients with senile depression and silent cerebral infarction (SCI) to clarify the features of the P300 component. P300 event-related potentials were recorded in drug-free depressed patients ( N=16) and normal controls ( N=17). All patients underwent magnetic...

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Bibliographic Details
Published in:Journal of affective disorders 1997-12, Vol.46 (3), p.263-271
Main Authors: Yanai, Ichiro, Fujikawa, Tokumi, Osada, Masashi, Yamawaki, Shigeto, Touhouda, Yoshikuni
Format: Article
Language:English
Subjects:
Age Factors
Aged
Antidepressive Agents - therapeutic use
Brain - pathology
Cerebral infarction
Cerebral Infarction - diagnosis
Cerebral Infarction - epidemiology
Cerebral Infarction - pathology
Comorbidity
Depression
Depressive Disorder - diagnosis
Depressive Disorder - drug therapy
Depressive Disorder - epidemiology
Event-related potentials
Event-Related Potentials, P300
Evoked Potentials, Auditory
Female
Humans
Japan - epidemiology
Magnetic Resonance Imaging
Male
Middle Aged
P300
Prospective Studies
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Summary:We examined event-related potentials in patients with senile depression and silent cerebral infarction (SCI) to clarify the features of the P300 component. P300 event-related potentials were recorded in drug-free depressed patients ( N=16) and normal controls ( N=17). All patients underwent magnetic resonance imaging and were classified as SCI-positive ( N=7) or SCI-negative ( N=9). In depressed patients, the P300 was reexamined after antidepressant treatment. Prior to treatment, P300 amplitudes in depressed patients were significantly smaller than those in normal controls ( P
ISSN:0165-0327
1573-2517
DOI:10.1016/S0165-0327(97)00100-6