Peripheral hemodynamic effects of ibopamine in patients with congestive heart failure. A placebo-controlled, double-blind study

Under double-blind conditions, 150 mg of ibopamine (di-isobutyric ester of N-methyldopamine) or placebo were given orally to 11 patients with congestive heart failure; after 3 hours, 50 mg of sulpiride were administered intramuscularly. Peripheral hemodynamics were evaluated at the level of the fore...

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Bibliographic Details
Published in:Cardiovascular drugs and therapy 1989-04, Vol.3 (2), p.199-202
Main Authors: Longhini, C, Ansani, L, Musacci, G F, Aggio, S, Baracca, E, Toselli, T, Ghirardi, P
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Deoxyepinephrine - analogs & derivatives
Deoxyepinephrine - therapeutic use
Double-Blind Method
Female
Heart Failure - drug therapy
Heart Failure - physiopathology
Heart Rate - drug effects
Hemodynamics - drug effects
Humans
Male
Middle Aged
Plethysmography
Regional Blood Flow - drug effects
Sulpiride - pharmacology
Vasodilator Agents - therapeutic use
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Summary:Under double-blind conditions, 150 mg of ibopamine (di-isobutyric ester of N-methyldopamine) or placebo were given orally to 11 patients with congestive heart failure; after 3 hours, 50 mg of sulpiride were administered intramuscularly. Peripheral hemodynamics were evaluated at the level of the forearm using strain-gauge plethysmography. Ibopamine increased arterial blood flow and venous capacity and decreased arterial peripheral resistance; these effects were counteracted by sulpiride. No significant changes were observed after placebo and sulpiride. These findings confirm the vasodilating effects of ibopamine on peripheral hemodynamics and its utility in patients for the treatment of congestive heart failure.
ISSN:0920-3206
1573-7241
DOI:10.1007/BF01883865