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Hemocue®, an accurate bedside method of hemoglobin measurement ?
Evaluate the accuracy of this bedside method to determine hemoglobin (Hb) concentration in general surgery over a wide range of Hb values and to determine potential sources of error. Accuracy of Hb measurement using HemoCue (AB Leo Diagnostics, Helsinborg, Sweden) was assessed in 140 surgical blood...
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Published in: | Journal of clinical monitoring 1997-11, Vol.13 (6), p.373-377 |
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creator | RIPPMANN, C. E NETT, P. C POPOVIC, D SEIFERT, B PASCH, T SPAHN, D. R |
description | Evaluate the accuracy of this bedside method to determine hemoglobin (Hb) concentration in general surgery over a wide range of Hb values and to determine potential sources of error.
Accuracy of Hb measurement using HemoCue (AB Leo Diagnostics, Helsinborg, Sweden) was assessed in 140 surgical blood samples using 7 HemoCue devices in comparison with a CO-Oximeter (IL 482, Instrumentation Laboratory, Lexington, MA). To analyze potential sources of error, packed red cells and fresh frozen plasma were reconstituted to randomized Hb levels of 2-18 g/dL.
In the surgical blood samples, the Hb concentration determined by the CO-Oximeter (HbCOOX) ranged from 5.1 to 16.7 g/dL and the Hb concentration measured by HemoCue (HbHC) from 4.7 to 16.0 g/dL. Bias (HbCOOX - HbHC) between HbCOOX and HbHC was 0.6+/-0.6 g/dL (mean +/- SD) or 5.4+/-5.0% (p < 0.001). Also in the reconstituted blood, the bias between HbCOOX and HbHC was significant (0.2+/-0.3 g/dL or 2.1+/-3.2%; p < 0.001). The microcuvette explained 68% of the variability between HbCOOX and HbHC. HemoCue thus underestimates the Hb concentration by 2-5% and exhibits a 8-10 times higher variability with only 86.4% of HbHC being within +/- 10% of HbCOOX. CONCLUSION. Although the mean bias between HbCOOX and HbHC was relatively low, Hb measurement by HemoCue exhibited a significant variability. Loading multiple microcuvettes and averaging the results may increase the accuracy of Hb measurement by HemoCue. |
doi_str_mv | 10.1023/A:1007451611748 |
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Accuracy of Hb measurement using HemoCue (AB Leo Diagnostics, Helsinborg, Sweden) was assessed in 140 surgical blood samples using 7 HemoCue devices in comparison with a CO-Oximeter (IL 482, Instrumentation Laboratory, Lexington, MA). To analyze potential sources of error, packed red cells and fresh frozen plasma were reconstituted to randomized Hb levels of 2-18 g/dL.
In the surgical blood samples, the Hb concentration determined by the CO-Oximeter (HbCOOX) ranged from 5.1 to 16.7 g/dL and the Hb concentration measured by HemoCue (HbHC) from 4.7 to 16.0 g/dL. Bias (HbCOOX - HbHC) between HbCOOX and HbHC was 0.6+/-0.6 g/dL (mean +/- SD) or 5.4+/-5.0% (p < 0.001). Also in the reconstituted blood, the bias between HbCOOX and HbHC was significant (0.2+/-0.3 g/dL or 2.1+/-3.2%; p < 0.001). The microcuvette explained 68% of the variability between HbCOOX and HbHC. HemoCue thus underestimates the Hb concentration by 2-5% and exhibits a 8-10 times higher variability with only 86.4% of HbHC being within +/- 10% of HbCOOX. CONCLUSION. Although the mean bias between HbCOOX and HbHC was relatively low, Hb measurement by HemoCue exhibited a significant variability. Loading multiple microcuvettes and averaging the results may increase the accuracy of Hb measurement by HemoCue.</description><identifier>ISSN: 0748-1977</identifier><identifier>ISSN: 1387-1307</identifier><identifier>EISSN: 2214-7330</identifier><identifier>EISSN: 1573-2614</identifier><identifier>DOI: 10.1023/A:1007451611748</identifier><identifier>PMID: 9495289</identifier><identifier>CODEN: JCMOEH</identifier><language>eng</language><publisher>Boston, MA: Little</publisher><subject>Bias ; Biological and medical sciences ; Blood ; Evaluation Studies as Topic ; Hematology ; Hemoglobinometry - instrumentation ; Hemoglobins - analysis ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Point-of-Care Systems</subject><ispartof>Journal of clinical monitoring, 1997-11, Vol.13 (6), p.373-377</ispartof><rights>1998 INIST-CNRS</rights><rights>Kluwer Academic Publishers 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-1b2ff3212144c4ef4f6e5a0c5fc4e69e5552a0f218defc571b2b5647108409643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2174409$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9495289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RIPPMANN, C. E</creatorcontrib><creatorcontrib>NETT, P. C</creatorcontrib><creatorcontrib>POPOVIC, D</creatorcontrib><creatorcontrib>SEIFERT, B</creatorcontrib><creatorcontrib>PASCH, T</creatorcontrib><creatorcontrib>SPAHN, D. R</creatorcontrib><title>Hemocue®, an accurate bedside method of hemoglobin measurement ?</title><title>Journal of clinical monitoring</title><addtitle>J Clin Monit</addtitle><description>Evaluate the accuracy of this bedside method to determine hemoglobin (Hb) concentration in general surgery over a wide range of Hb values and to determine potential sources of error.
Accuracy of Hb measurement using HemoCue (AB Leo Diagnostics, Helsinborg, Sweden) was assessed in 140 surgical blood samples using 7 HemoCue devices in comparison with a CO-Oximeter (IL 482, Instrumentation Laboratory, Lexington, MA). To analyze potential sources of error, packed red cells and fresh frozen plasma were reconstituted to randomized Hb levels of 2-18 g/dL.
In the surgical blood samples, the Hb concentration determined by the CO-Oximeter (HbCOOX) ranged from 5.1 to 16.7 g/dL and the Hb concentration measured by HemoCue (HbHC) from 4.7 to 16.0 g/dL. Bias (HbCOOX - HbHC) between HbCOOX and HbHC was 0.6+/-0.6 g/dL (mean +/- SD) or 5.4+/-5.0% (p < 0.001). Also in the reconstituted blood, the bias between HbCOOX and HbHC was significant (0.2+/-0.3 g/dL or 2.1+/-3.2%; p < 0.001). The microcuvette explained 68% of the variability between HbCOOX and HbHC. HemoCue thus underestimates the Hb concentration by 2-5% and exhibits a 8-10 times higher variability with only 86.4% of HbHC being within +/- 10% of HbCOOX. CONCLUSION. Although the mean bias between HbCOOX and HbHC was relatively low, Hb measurement by HemoCue exhibited a significant variability. Loading multiple microcuvettes and averaging the results may increase the accuracy of Hb measurement by HemoCue.</description><subject>Bias</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Evaluation Studies as Topic</subject><subject>Hematology</subject><subject>Hemoglobinometry - instrumentation</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Point-of-Care Systems</subject><issn>0748-1977</issn><issn>1387-1307</issn><issn>2214-7330</issn><issn>1573-2614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNpdkM1KxDAUhYMo4zi6diUEEVdW89s0bqQM6ggDbnRd0vTG6dA2Y9MufCkfwiczYnHh6t57zsflcBA6peSaEsZv8ltKiBKSppQqke2hOWNUJIpzso_m0ckSqpU6REchbAkhLNNshmZaaBnXOcpX0Ho7wtfnFTYdNtaOvRkAl1CFugLcwrDxFfYObyL41viy7qJowthDC92A747RgTNNgJNpLtDrw_3LcpWsnx-flvk6sVzoIaElc44zGtMJK8AJl4I0xEoXr1SDlJIZ4hjNKnBWqsiXMhWKkkwQnQq-QJe_f3e9fx8hDEVbBwtNYzrwYyiUloqwVEbw_B-49WPfxWxFlnKuhVI_0NkEjWULVbHr69b0H8VUTPQvJt8EaxrXm87W4Q9jsewYi38D_ZNwCA</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>RIPPMANN, C. E</creator><creator>NETT, P. C</creator><creator>POPOVIC, D</creator><creator>SEIFERT, B</creator><creator>PASCH, T</creator><creator>SPAHN, D. 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E ; NETT, P. C ; POPOVIC, D ; SEIFERT, B ; PASCH, T ; SPAHN, D. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-1b2ff3212144c4ef4f6e5a0c5fc4e69e5552a0f218defc571b2b5647108409643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Bias</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Evaluation Studies as Topic</topic><topic>Hematology</topic><topic>Hemoglobinometry - instrumentation</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Point-of-Care Systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RIPPMANN, C. E</creatorcontrib><creatorcontrib>NETT, P. 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E</au><au>NETT, P. C</au><au>POPOVIC, D</au><au>SEIFERT, B</au><au>PASCH, T</au><au>SPAHN, D. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemocue®, an accurate bedside method of hemoglobin measurement ?</atitle><jtitle>Journal of clinical monitoring</jtitle><addtitle>J Clin Monit</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>13</volume><issue>6</issue><spage>373</spage><epage>377</epage><pages>373-377</pages><issn>0748-1977</issn><issn>1387-1307</issn><eissn>2214-7330</eissn><eissn>1573-2614</eissn><coden>JCMOEH</coden><abstract>Evaluate the accuracy of this bedside method to determine hemoglobin (Hb) concentration in general surgery over a wide range of Hb values and to determine potential sources of error.
Accuracy of Hb measurement using HemoCue (AB Leo Diagnostics, Helsinborg, Sweden) was assessed in 140 surgical blood samples using 7 HemoCue devices in comparison with a CO-Oximeter (IL 482, Instrumentation Laboratory, Lexington, MA). To analyze potential sources of error, packed red cells and fresh frozen plasma were reconstituted to randomized Hb levels of 2-18 g/dL.
In the surgical blood samples, the Hb concentration determined by the CO-Oximeter (HbCOOX) ranged from 5.1 to 16.7 g/dL and the Hb concentration measured by HemoCue (HbHC) from 4.7 to 16.0 g/dL. Bias (HbCOOX - HbHC) between HbCOOX and HbHC was 0.6+/-0.6 g/dL (mean +/- SD) or 5.4+/-5.0% (p < 0.001). Also in the reconstituted blood, the bias between HbCOOX and HbHC was significant (0.2+/-0.3 g/dL or 2.1+/-3.2%; p < 0.001). The microcuvette explained 68% of the variability between HbCOOX and HbHC. HemoCue thus underestimates the Hb concentration by 2-5% and exhibits a 8-10 times higher variability with only 86.4% of HbHC being within +/- 10% of HbCOOX. CONCLUSION. Although the mean bias between HbCOOX and HbHC was relatively low, Hb measurement by HemoCue exhibited a significant variability. Loading multiple microcuvettes and averaging the results may increase the accuracy of Hb measurement by HemoCue.</abstract><cop>Boston, MA</cop><pub>Little</pub><pmid>9495289</pmid><doi>10.1023/A:1007451611748</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Bias Biological and medical sciences Blood Evaluation Studies as Topic Hematology Hemoglobinometry - instrumentation Hemoglobins - analysis Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Point-of-Care Systems |
title | Hemocue®, an accurate bedside method of hemoglobin measurement ? |
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