Macroschizonts of Theileria annulata as vaccine and diagnostic tools

T. annulata-infected cells present infection-associated peptides. These peptides represent target molecules of the cytotoxic acting cells. Their preparation and characterization may help to develop a sub-unit vaccine. Our studies show that macroschizont-infected bovine cells can be used as parasite...

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Bibliographic Details
Published in:Tropical animal health and production 1997-11, Vol.29 (4 Suppl), p.128S-132S
Main Authors: Ahmed, J S, Shayan, P, Hugel, F U, Biermann, R, Ewald, C, Schein, E, Gerdes, J
Format: Article
Language:English
Subjects:
Animals
Antibodies, Protozoan - blood
Antigens, Protozoan - analysis
Antigens, Protozoan - immunology
Carrier State - diagnosis
Carrier State - veterinary
Cattle
Cattle Diseases - diagnosis
Cattle Diseases - immunology
Cattle Diseases - parasitology
Lymphocyte Activation
Polymerase Chain Reaction
Protozoan Vaccines
Theileria annulata - chemistry
Theileria annulata - growth & development
Theileria annulata - immunology
Theileriasis - diagnosis
Theileriasis - immunology
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Summary:T. annulata-infected cells present infection-associated peptides. These peptides represent target molecules of the cytotoxic acting cells. Their preparation and characterization may help to develop a sub-unit vaccine. Our studies show that macroschizont-infected bovine cells can be used as parasite antigen in serology for the detection of parasite-specific antibodies in serum of infected animals. Primers derived from the macroschizont of T. annulata can be used as molecular tools for the detection of parasite DNA in blood samples of carrier cattle.
ISSN:0049-4747
DOI:10.1007/BF02632952