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Determination of encainide and its metabolites by high-performance liquid chromatography
Encainide (ENC) and its metabolites O-demethylencainide (ODE), 3-methoxy- O-demethylencainide (MODE), N-demethylencainide (NDE) and bis- N,O-demethylencainide (NODE) have been measured by two HPLC procedures. The method of Mayol using a μPorasil column with ethanol—water—methanesulphonic acid as mob...
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| Published in: | Journal of pharmaceutical and biomedical analysis 1989, Vol.7 (3), p.355-359 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| container_end_page | 359 |
| container_issue | 3 |
| container_start_page | 355 |
| container_title | Journal of pharmaceutical and biomedical analysis |
| container_volume | 7 |
| creator | Selinger, K. Crawhall, J.C. |
| description | Encainide (ENC) and its metabolites
O-demethylencainide (ODE), 3-methoxy-
O-demethylencainide (MODE),
N-demethylencainide (NDE) and bis-
N,O-demethylencainide (NODE) have been measured by two HPLC procedures. The method of Mayol using a μPorasil column with ethanol—water—methanesulphonic acid as mobile phase was not able to separately measure NODE and NDE in plasma. A new method is described using a μBondapak Phenyl column with acetonitrile—phosphate buffer (0.05 M, pH 7.5) that yields satisfactory separation of ENC and its metabolites. NODE was not identified as a metabolite in 23 patients analysed. |
| doi_str_mv | 10.1016/0731-7085(89)80102-5 |
| format | article |
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O-demethylencainide (ODE), 3-methoxy-
O-demethylencainide (MODE),
N-demethylencainide (NDE) and bis-
N,O-demethylencainide (NODE) have been measured by two HPLC procedures. The method of Mayol using a μPorasil column with ethanol—water—methanesulphonic acid as mobile phase was not able to separately measure NODE and NDE in plasma. A new method is described using a μBondapak Phenyl column with acetonitrile—phosphate buffer (0.05 M, pH 7.5) that yields satisfactory separation of ENC and its metabolites. NODE was not identified as a metabolite in 23 patients analysed.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/0731-7085(89)80102-5</identifier><identifier>PMID: 2518704</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Anilides - analysis ; Anilides - blood ; Anilides - metabolism ; Anti-Arrhythmia Agents - analysis ; Anti-Arrhythmia Agents - blood ; Anti-Arrhythmia Agents - metabolism ; Biological and medical sciences ; Biotransformation ; Chromatography, High Pressure Liquid ; Dealkylation ; Encainide ; Encainide metabolites ; General pharmacology ; HPLC ; Humans ; Medical sciences ; metabolic demethylation ; Pharmacology. Drug treatments ; Spectrophotometry, Ultraviolet</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 1989, Vol.7 (3), p.355-359</ispartof><rights>1989</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c335t-cea948877d224aad072e4fc5b610074fbefda3c4a3033b6f8eaa176f1cdf5c6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0731708589801025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3619,4024,27923,27924,27925,45983</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7264992$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2518704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Selinger, K.</creatorcontrib><creatorcontrib>Crawhall, J.C.</creatorcontrib><title>Determination of encainide and its metabolites by high-performance liquid chromatography</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>Encainide (ENC) and its metabolites
O-demethylencainide (ODE), 3-methoxy-
O-demethylencainide (MODE),
N-demethylencainide (NDE) and bis-
N,O-demethylencainide (NODE) have been measured by two HPLC procedures. The method of Mayol using a μPorasil column with ethanol—water—methanesulphonic acid as mobile phase was not able to separately measure NODE and NDE in plasma. A new method is described using a μBondapak Phenyl column with acetonitrile—phosphate buffer (0.05 M, pH 7.5) that yields satisfactory separation of ENC and its metabolites. NODE was not identified as a metabolite in 23 patients analysed.</description><subject>Analysis</subject><subject>Anilides - analysis</subject><subject>Anilides - blood</subject><subject>Anilides - metabolism</subject><subject>Anti-Arrhythmia Agents - analysis</subject><subject>Anti-Arrhythmia Agents - blood</subject><subject>Anti-Arrhythmia Agents - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biotransformation</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dealkylation</subject><subject>Encainide</subject><subject>Encainide metabolites</subject><subject>General pharmacology</subject><subject>HPLC</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>metabolic demethylation</subject><subject>Pharmacology. Drug treatments</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNp9kUFrFDEUx4ModVv9Bgo5iNTD1GSSTGYuBalaCwUvCr2FN8lLNzIz2SbZwn57s-6yR0_v8P-9P4_fI-QdZ1ec8e4z04I3mvXqsh8-9YyztlEvyIr3WjRtJx9ektUJeU3Oc_7DGFN8kGfkrFUVY3JFHr5iwTSHBUqIC42e4mIhLMEhhcXRUDKdscAYp1Aw03FH1-Fx3Www-ZhmWCzSKTxtg6N2neIMJT4m2Kx3b8grD1PGt8d5QX5___br5kdz__P27ubLfWOFUKWxCIPse61d20oAx3SL0ls1dpwxLf2I3oGwEgQTYux8jwBcd55b55XtvLggHw-9mxSftpiLmUO2OE2wYNxmowelJWtFBeUBtCnmnNCbTQozpJ3hzOyFmr0ts7dl-sH8E2pUXXt_7N-OM7rT0tFgzT8cc8gWJp-qkpBPmK6fGIa2YtcHDKuL54DJZBuqanQhoS3GxfD_O_4CzYSTiw</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Selinger, K.</creator><creator>Crawhall, J.C.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Determination of encainide and its metabolites by high-performance liquid chromatography</title><author>Selinger, K. ; Crawhall, J.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-cea948877d224aad072e4fc5b610074fbefda3c4a3033b6f8eaa176f1cdf5c6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Analysis</topic><topic>Anilides - analysis</topic><topic>Anilides - blood</topic><topic>Anilides - metabolism</topic><topic>Anti-Arrhythmia Agents - analysis</topic><topic>Anti-Arrhythmia Agents - blood</topic><topic>Anti-Arrhythmia Agents - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biotransformation</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dealkylation</topic><topic>Encainide</topic><topic>Encainide metabolites</topic><topic>General pharmacology</topic><topic>HPLC</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>metabolic demethylation</topic><topic>Pharmacology. Drug treatments</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Selinger, K.</creatorcontrib><creatorcontrib>Crawhall, J.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Selinger, K.</au><au>Crawhall, J.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of encainide and its metabolites by high-performance liquid chromatography</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>1989</date><risdate>1989</risdate><volume>7</volume><issue>3</issue><spage>355</spage><epage>359</epage><pages>355-359</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>Encainide (ENC) and its metabolites
O-demethylencainide (ODE), 3-methoxy-
O-demethylencainide (MODE),
N-demethylencainide (NDE) and bis-
N,O-demethylencainide (NODE) have been measured by two HPLC procedures. The method of Mayol using a μPorasil column with ethanol—water—methanesulphonic acid as mobile phase was not able to separately measure NODE and NDE in plasma. A new method is described using a μBondapak Phenyl column with acetonitrile—phosphate buffer (0.05 M, pH 7.5) that yields satisfactory separation of ENC and its metabolites. NODE was not identified as a metabolite in 23 patients analysed.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2518704</pmid><doi>10.1016/0731-7085(89)80102-5</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 1989, Vol.7 (3), p.355-359 |
| issn | 0731-7085 1873-264X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79574023 |
| source | ScienceDirect Physical & Analytical Chemistry Backfile |
| subjects | Analysis Anilides - analysis Anilides - blood Anilides - metabolism Anti-Arrhythmia Agents - analysis Anti-Arrhythmia Agents - blood Anti-Arrhythmia Agents - metabolism Biological and medical sciences Biotransformation Chromatography, High Pressure Liquid Dealkylation Encainide Encainide metabolites General pharmacology HPLC Humans Medical sciences metabolic demethylation Pharmacology. Drug treatments Spectrophotometry, Ultraviolet |
| title | Determination of encainide and its metabolites by high-performance liquid chromatography |
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