The effect of transdermal 17- β-estradiol on glucose metabolism of postmenopausal women is evident during the oral but not the intravenous glucose administration

Objectives: To evaluate the effect of transdermal 17- β-estradiol (50 μg/day) on glucose metabolism of postmenopausal women. Study design: A frequently sampled intravenous glucose tolerance test (FSIGT), to calculate insulin sensitivity ( S I) and peripheral glucose utilization independent of insuli...

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Bibliographic Details
Published in:Maturitas 1997-12, Vol.28 (2), p.163-167
Main Authors: Cagnacci, Angelo, Tuveri, Federica, Cirillo, Rocco, Setteneri, Anna Maria, Melis, Gian Benedetto, Volpe, Annibale
Format: Article
Language:English
Subjects:
17- β-Estradiol
Administration, Cutaneous
Administration, Oral
Biological and medical sciences
Blood Glucose - analysis
Blood Glucose - drug effects
Blood Glucose - metabolism
C-Peptide - blood
C-Peptide - drug effects
C-Peptide - metabolism
Estradiol - administration & dosage
Estradiol - pharmacology
Fasting
Female
Glucose - administration & dosage
Glucose metabolism
Glucose Tolerance Test - methods
Hormones. Endocrine system
Humans
Injections, Intravenous
Insulin - blood
Insulin - metabolism
Medical sciences
Menopause
Middle Aged
Pharmacology. Drug treatments
Postmenopause - drug effects
Postmenopause - metabolism
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Summary:Objectives: To evaluate the effect of transdermal 17- β-estradiol (50 μg/day) on glucose metabolism of postmenopausal women. Study design: A frequently sampled intravenous glucose tolerance test (FSIGT), to calculate insulin sensitivity ( S I) and peripheral glucose utilization independent of insulin ( S G), and an oral glucose tolerance test (75 g; OGTT), were performed in nine postmenopausal women prior to, and after 2 months of, treatment. Results: Estradiol decreased insulin and increased the C-peptide/insulin ratio both during fasting ( P
ISSN:0378-5122
1873-4111
DOI:10.1016/S0378-5122(97)00064-9