The determination of fenspiride in human plasma and urine by liquid chromatography with electrochemical or ultraviolet detection

A selective and sensitive method for the determination of fenspiride in biological fluids is described. The method involves liquid—liquid extraction followed by separation on a reversed-phase column with electrochemical detection for low levels of the drug in plasma (⩽ 100 ng ml −1) or UV absorption...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1989, Vol.7 (12), p.1799-1804
Main Authors: Sauveur, C., Baune, A., Vergnes, N., Jeanniot, J.Ph
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Chromatography, Liquid
dual detection
Electrochemistry
Fenspiride
General pharmacology
Humans
Indicators and Reagents
Medical sciences
Pharmacology. Drug treatments
reversed-phase liquid chromatography
Spectrophotometry, Ultraviolet
Spiro Compounds - analysis
Spiro Compounds - blood
Spiro Compounds - urine
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Description
Summary:A selective and sensitive method for the determination of fenspiride in biological fluids is described. The method involves liquid—liquid extraction followed by separation on a reversed-phase column with electrochemical detection for low levels of the drug in plasma (⩽ 100 ng ml −1) or UV absorption for higher concentrations in plasma or urine. The method is suitable for pharmacokinetic analyses and drug monitoring studies.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(89)80196-7