Determination of benzalkonium chloride in contact lens solutions by positive-ion fast atom bombardment mass spectrometry

Under positive-ion fast atom bombardment (FAB) mass spectrometric conditions, benzalkonium chloride (BAK) afforded intense peaks at m/z 304 and 332, corresponding to the intact cations [MCl] + of C 12 and C 14 homologues, respectively. The use of benzethonium chloride as an internal standard and th...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1989, Vol.7 (12), p.1611-1616
Main Authors: Pinzauti, S., Bambagiotti-Alberti, M., Moneti, G., La Porta, E., Coran, S.A., Vincieri, F.F., Gratteri, P.
Format: Article
Language:English
Subjects:
Analysis
benzalkonium chloride determination
Benzalkonium Compounds - analysis
Biological and medical sciences
contact lens solutions
Contact Lenses
FAB mass spectrometry
General pharmacology
Italy
Medical sciences
Pharmacology. Drug treatments
Solutions
Spectrometry, Mass, Fast Atom Bombardment
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Summary:Under positive-ion fast atom bombardment (FAB) mass spectrometric conditions, benzalkonium chloride (BAK) afforded intense peaks at m/z 304 and 332, corresponding to the intact cations [MCl] + of C 12 and C 14 homologues, respectively. The use of benzethonium chloride as an internal standard and thioglycerol as a FAB matrix allowed the direct and specific determination of the BAK content (0.004–0.020%) in commercial hard contact lens solutions through the individual assay of the two alkyl homologues. A linear relationship between the homologue concentration and the peak—area ratio was observed over the concentration range 3–180 μg ml −1.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(89)80172-4