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Determination of benzalkonium chloride in contact lens solutions by positive-ion fast atom bombardment mass spectrometry
Under positive-ion fast atom bombardment (FAB) mass spectrometric conditions, benzalkonium chloride (BAK) afforded intense peaks at m/z 304 and 332, corresponding to the intact cations [MCl] + of C 12 and C 14 homologues, respectively. The use of benzethonium chloride as an internal standard and th...
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| Published in: | Journal of pharmaceutical and biomedical analysis 1989, Vol.7 (12), p.1611-1616 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c387t-6edd77bf7192a8f19661e3591011154a92415ab3ad1b00e993cffbc791871ed13 |
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| cites | cdi_FETCH-LOGICAL-c387t-6edd77bf7192a8f19661e3591011154a92415ab3ad1b00e993cffbc791871ed13 |
| container_end_page | 1616 |
| container_issue | 12 |
| container_start_page | 1611 |
| container_title | Journal of pharmaceutical and biomedical analysis |
| container_volume | 7 |
| creator | Pinzauti, S. Bambagiotti-Alberti, M. Moneti, G. La Porta, E. Coran, S.A. Vincieri, F.F. Gratteri, P. |
| description | Under positive-ion fast atom bombardment (FAB) mass spectrometric conditions, benzalkonium chloride (BAK) afforded intense peaks at
m/z 304 and 332, corresponding to the intact cations [MCl]
+ of C
12 and C
14 homologues, respectively. The use of benzethonium chloride as an internal standard and thioglycerol as a FAB matrix allowed the direct and specific determination of the BAK content (0.004–0.020%) in commercial hard contact lens solutions through the individual assay of the two alkyl homologues. A linear relationship between the homologue concentration and the peak—area ratio was observed over the concentration range 3–180 μg ml
−1. |
| doi_str_mv | 10.1016/0731-7085(89)80172-4 |
| format | article |
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m/z 304 and 332, corresponding to the intact cations [MCl]
+ of C
12 and C
14 homologues, respectively. The use of benzethonium chloride as an internal standard and thioglycerol as a FAB matrix allowed the direct and specific determination of the BAK content (0.004–0.020%) in commercial hard contact lens solutions through the individual assay of the two alkyl homologues. A linear relationship between the homologue concentration and the peak—area ratio was observed over the concentration range 3–180 μg ml
−1.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/0731-7085(89)80172-4</identifier><identifier>PMID: 2490550</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; benzalkonium chloride determination ; Benzalkonium Compounds - analysis ; Biological and medical sciences ; contact lens solutions ; Contact Lenses ; FAB mass spectrometry ; General pharmacology ; Italy ; Medical sciences ; Pharmacology. Drug treatments ; Solutions ; Spectrometry, Mass, Fast Atom Bombardment</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 1989, Vol.7 (12), p.1611-1616</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-6edd77bf7192a8f19661e3591011154a92415ab3ad1b00e993cffbc791871ed13</citedby><cites>FETCH-LOGICAL-c387t-6edd77bf7192a8f19661e3591011154a92415ab3ad1b00e993cffbc791871ed13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0731708589801724$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3619,4024,4050,4051,23930,23931,25140,27923,27924,27925,45983</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19336497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2490550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinzauti, S.</creatorcontrib><creatorcontrib>Bambagiotti-Alberti, M.</creatorcontrib><creatorcontrib>Moneti, G.</creatorcontrib><creatorcontrib>La Porta, E.</creatorcontrib><creatorcontrib>Coran, S.A.</creatorcontrib><creatorcontrib>Vincieri, F.F.</creatorcontrib><creatorcontrib>Gratteri, P.</creatorcontrib><title>Determination of benzalkonium chloride in contact lens solutions by positive-ion fast atom bombardment mass spectrometry</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>Under positive-ion fast atom bombardment (FAB) mass spectrometric conditions, benzalkonium chloride (BAK) afforded intense peaks at
m/z 304 and 332, corresponding to the intact cations [MCl]
+ of C
12 and C
14 homologues, respectively. The use of benzethonium chloride as an internal standard and thioglycerol as a FAB matrix allowed the direct and specific determination of the BAK content (0.004–0.020%) in commercial hard contact lens solutions through the individual assay of the two alkyl homologues. A linear relationship between the homologue concentration and the peak—area ratio was observed over the concentration range 3–180 μg ml
−1.</description><subject>Analysis</subject><subject>benzalkonium chloride determination</subject><subject>Benzalkonium Compounds - analysis</subject><subject>Biological and medical sciences</subject><subject>contact lens solutions</subject><subject>Contact Lenses</subject><subject>FAB mass spectrometry</subject><subject>General pharmacology</subject><subject>Italy</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Solutions</subject><subject>Spectrometry, Mass, Fast Atom Bombardment</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNp9kEuLFDEUhYMoY8_oP1DIRhkXpUlVqlLZDMj4hAE3Cu5CHjcYrSRtkhpsf70puxl3ru7ifOdw-RB6QslLSuj0ivCBdpzM4-UsXsyE8r5j99COznzo-ol9vY92d8hDdF7Kd0LISAU7Q2c9E2QcyQ79egMVcvBRVZ8iTg5riL_V8iNFvwZsvi0pewvYR2xSrMpUvEAsuKRl3RoF6wPep-Krv4Vum3CqVKxqClinoFW2AWLFQZVW2oOpOQWo-fAIPXBqKfD4dC_Ql3dvP19_6G4-vf94_fqmM8PMazeBtZxrx6no1eyomCYKwyiaAUpHpkTP6Kj0oCzVhIAQg3FOGy6aBgqWDhfo-XF3n9PPFUqVwRcDy6IipLVILkYuxCgayI6gyamUDE7usw8qHyQlchMuN5tysylnIf8Kl6zVnp72Vx3A3pVOhlv-7JSrYtTisorGl3_bYhgmJnjjro4cNBm3HrIsxkM0YH1u1qRN_v-P_AGREp8c</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Pinzauti, S.</creator><creator>Bambagiotti-Alberti, M.</creator><creator>Moneti, G.</creator><creator>La Porta, E.</creator><creator>Coran, S.A.</creator><creator>Vincieri, F.F.</creator><creator>Gratteri, P.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Determination of benzalkonium chloride in contact lens solutions by positive-ion fast atom bombardment mass spectrometry</title><author>Pinzauti, S. ; Bambagiotti-Alberti, M. ; Moneti, G. ; La Porta, E. ; Coran, S.A. ; Vincieri, F.F. ; Gratteri, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-6edd77bf7192a8f19661e3591011154a92415ab3ad1b00e993cffbc791871ed13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Analysis</topic><topic>benzalkonium chloride determination</topic><topic>Benzalkonium Compounds - analysis</topic><topic>Biological and medical sciences</topic><topic>contact lens solutions</topic><topic>Contact Lenses</topic><topic>FAB mass spectrometry</topic><topic>General pharmacology</topic><topic>Italy</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Solutions</topic><topic>Spectrometry, Mass, Fast Atom Bombardment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pinzauti, S.</creatorcontrib><creatorcontrib>Bambagiotti-Alberti, M.</creatorcontrib><creatorcontrib>Moneti, G.</creatorcontrib><creatorcontrib>La Porta, E.</creatorcontrib><creatorcontrib>Coran, S.A.</creatorcontrib><creatorcontrib>Vincieri, F.F.</creatorcontrib><creatorcontrib>Gratteri, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pinzauti, S.</au><au>Bambagiotti-Alberti, M.</au><au>Moneti, G.</au><au>La Porta, E.</au><au>Coran, S.A.</au><au>Vincieri, F.F.</au><au>Gratteri, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of benzalkonium chloride in contact lens solutions by positive-ion fast atom bombardment mass spectrometry</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>1989</date><risdate>1989</risdate><volume>7</volume><issue>12</issue><spage>1611</spage><epage>1616</epage><pages>1611-1616</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>Under positive-ion fast atom bombardment (FAB) mass spectrometric conditions, benzalkonium chloride (BAK) afforded intense peaks at
m/z 304 and 332, corresponding to the intact cations [MCl]
+ of C
12 and C
14 homologues, respectively. The use of benzethonium chloride as an internal standard and thioglycerol as a FAB matrix allowed the direct and specific determination of the BAK content (0.004–0.020%) in commercial hard contact lens solutions through the individual assay of the two alkyl homologues. A linear relationship between the homologue concentration and the peak—area ratio was observed over the concentration range 3–180 μg ml
−1.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2490550</pmid><doi>10.1016/0731-7085(89)80172-4</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 1989, Vol.7 (12), p.1611-1616 |
| issn | 0731-7085 1873-264X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79579959 |
| source | Elsevier SD Backfile Physical and Analytical Chemistry |
| subjects | Analysis benzalkonium chloride determination Benzalkonium Compounds - analysis Biological and medical sciences contact lens solutions Contact Lenses FAB mass spectrometry General pharmacology Italy Medical sciences Pharmacology. Drug treatments Solutions Spectrometry, Mass, Fast Atom Bombardment |
| title | Determination of benzalkonium chloride in contact lens solutions by positive-ion fast atom bombardment mass spectrometry |
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