Synthesis of DHPA analogs and their inhibitory activities of human recombinant S-adenosyl-L-homocysteine hydrolase

We report syntheses of DHPA analogs, e.g., 9-(3-formyl-2,3-dihydroxypropyl)adenine (FDHPA) and 9-(3-formyl-2,3-dihydroxypropyl)hypoxanthine (FDHPI). Among these DHPA analogs, FDHPA behaved as an irreversible inactivator of human recombinant SAH hydrolase.

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Bibliographic Details
Published in:Nucleic acids symposium series (1979) 1997 (37), p.11-12
Main Authors: Kitade, Y, Nakanishi, M, Hosoya, A, Hiraoka, A, Hayashi, M, Mori, K, Gotoh, T, Yatome, C
Format: Article
Language:English
Subjects:
Adenine - analogs & derivatives
Adenine - chemical synthesis
Adenine - chemistry
Adenine - pharmacology
Adenosylhomocysteinase
Antiviral Agents - chemical synthesis
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Carcinoma, Hepatocellular
Drug Design
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Humans
Hydrolases - antagonists & inhibitors
Kinetics
Liver Neoplasms
Recombinant Proteins - antagonists & inhibitors
Tumor Cells, Cultured
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Description
Summary:We report syntheses of DHPA analogs, e.g., 9-(3-formyl-2,3-dihydroxypropyl)adenine (FDHPA) and 9-(3-formyl-2,3-dihydroxypropyl)hypoxanthine (FDHPI). Among these DHPA analogs, FDHPA behaved as an irreversible inactivator of human recombinant SAH hydrolase.
ISSN:0261-3166