The effect of quercetin on cell cycle progression and growth of human gastric cancer cells

Quercetin, a flavonoid, is found in many plants, including edible fruits and vegetables. We examined the effects on cell growth of human malignant cells derived from the gastrointestinal tract and on cell cycle progression. Quercetin markedly inhibited the growth of human gastric cancer cells and th...

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Bibliographic Details
Published in:FEBS letters 1990-01, Vol.260 (1), p.10-13
Main Authors: Yoshida, Mitsumori, Sakai, Toshiyuki, Hosokawa, Nobuko, Marui, Nobuyuki, Matsumoto, Katsuhiko, Fujioka, Akihiro, Nishino, Hoyoku, Aoike, Akira
Format: Article
Language:English
Subjects:
Antineoplastic Agents
Biological and medical sciences
Cell cycle
Cell Cycle - drug effects
Cell Survival - drug effects
DNA, Neoplasm - biosynthesis
Flavonoids - pharmacology
General aspects
Human gastric cancer cell
Humans
Medical sciences
Pharmacology. Drug treatments
Quercetin
Quercetin - administration & dosage
Quercetin - pharmacology
Starvation
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Tumor Cells, Cultured - drug effects
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Summary:Quercetin, a flavonoid, is found in many plants, including edible fruits and vegetables. We examined the effects on cell growth of human malignant cells derived from the gastrointestinal tract and on cell cycle progression. Quercetin markedly inhibited the growth of human gastric cancer cells and the IC 50 value was 32–55 μM. DNA synthesis was suppressed to 14% of the control level by the treatment with 70 μM quercetin for 2 days. Furthermore, quercetin blocked cell progression from the G 1 to the S phase.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(90)80053-L