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The effect of quercetin on cell cycle progression and growth of human gastric cancer cells
Quercetin, a flavonoid, is found in many plants, including edible fruits and vegetables. We examined the effects on cell growth of human malignant cells derived from the gastrointestinal tract and on cell cycle progression. Quercetin markedly inhibited the growth of human gastric cancer cells and th...
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| Published in: | FEBS letters 1990-01, Vol.260 (1), p.10-13 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c598L-b5e83763bf80be851b4036b0acf9e66e66176f0e7dcb662b248ea8bdc8a674943 |
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| cites | cdi_FETCH-LOGICAL-c598L-b5e83763bf80be851b4036b0acf9e66e66176f0e7dcb662b248ea8bdc8a674943 |
| container_end_page | 13 |
| container_issue | 1 |
| container_start_page | 10 |
| container_title | FEBS letters |
| container_volume | 260 |
| creator | Yoshida, Mitsumori Sakai, Toshiyuki Hosokawa, Nobuko Marui, Nobuyuki Matsumoto, Katsuhiko Fujioka, Akihiro Nishino, Hoyoku Aoike, Akira |
| description | Quercetin, a flavonoid, is found in many plants, including edible fruits and vegetables. We examined the effects on cell growth of human malignant cells derived from the gastrointestinal tract and on cell cycle progression. Quercetin markedly inhibited the growth of human gastric cancer cells and the
IC
50 value was 32–55 μM. DNA synthesis was suppressed to 14% of the control level by the treatment with 70 μM quercetin for 2 days. Furthermore, quercetin blocked cell progression from the G
1 to the S phase. |
| doi_str_mv | 10.1016/0014-5793(90)80053-L |
| format | article |
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IC
50 value was 32–55 μM. DNA synthesis was suppressed to 14% of the control level by the treatment with 70 μM quercetin for 2 days. Furthermore, quercetin blocked cell progression from the G
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IC
50 value was 32–55 μM. DNA synthesis was suppressed to 14% of the control level by the treatment with 70 μM quercetin for 2 days. Furthermore, quercetin blocked cell progression from the G
1 to the S phase.</description><subject>Antineoplastic Agents</subject><subject>Biological and medical sciences</subject><subject>Cell cycle</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>DNA, Neoplasm - biosynthesis</subject><subject>Flavonoids - pharmacology</subject><subject>General aspects</subject><subject>Human gastric cancer cell</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Quercetin</subject><subject>Quercetin - administration & dosage</subject><subject>Quercetin - pharmacology</subject><subject>Starvation</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Tumor Cells, Cultured - drug effects</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNqNUU2LFDEUDKKs4-o_UMhF0UNrPjpfF0GXHRUavKwXLyFJv8xEerrXpMdl_r3pmWG9qRAIea-qXqUeQs8peUsJle8IoW0jlOGvDXmjCRG86R6gFdWKN7yV-iFa3UMeoyel_CD1ram5QBeMGc20WaHvN1vAECOEGU8R_9xDDjCnEU8jDjAMOBzCAPg2T5sMpaRadmOPN3m6m7cLY7vfuRFvXJlzCji4MUA-MstT9Ci6ocCz832Jvq2vb64-N93XT1-uPnRNEEZ3jReguZLcR008aEF9S7j0xIVoQMp6qJKRgOqDl5J51mpw2vdBO6la0_JL9OqkW01W_2W2u1QWB26EaV-sMsIww-Q_gVQoKXgrKrA9AUOeSskQ7W1OO5cPlhK7ZG-XYO0SrDXEHrO3XaW9OOvv_Q76e9I57Np_ee67EtwQcw0rlT_aRnHFBK249Ql3lwY4_Ndsu77-yJbGUjfkWF0MvT8JQY3_V4JsS0hQN9SnXBdu-yn9_Ue_AYuts3s</recordid><startdate>19900115</startdate><enddate>19900115</enddate><creator>Yoshida, Mitsumori</creator><creator>Sakai, Toshiyuki</creator><creator>Hosokawa, Nobuko</creator><creator>Marui, Nobuyuki</creator><creator>Matsumoto, Katsuhiko</creator><creator>Fujioka, Akihiro</creator><creator>Nishino, Hoyoku</creator><creator>Aoike, Akira</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19900115</creationdate><title>The effect of quercetin on cell cycle progression and growth of human gastric cancer cells</title><author>Yoshida, Mitsumori ; Sakai, Toshiyuki ; Hosokawa, Nobuko ; Marui, Nobuyuki ; Matsumoto, Katsuhiko ; Fujioka, Akihiro ; Nishino, Hoyoku ; Aoike, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c598L-b5e83763bf80be851b4036b0acf9e66e66176f0e7dcb662b248ea8bdc8a674943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Antineoplastic Agents</topic><topic>Biological and medical sciences</topic><topic>Cell cycle</topic><topic>Cell Cycle - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>DNA, Neoplasm - biosynthesis</topic><topic>Flavonoids - pharmacology</topic><topic>General aspects</topic><topic>Human gastric cancer cell</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. 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IC
50 value was 32–55 μM. DNA synthesis was suppressed to 14% of the control level by the treatment with 70 μM quercetin for 2 days. Furthermore, quercetin blocked cell progression from the G
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| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1990-01, Vol.260 (1), p.10-13 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79592926 |
| source | Elsevier ScienceDirect Journals |
| subjects | Antineoplastic Agents Biological and medical sciences Cell cycle Cell Cycle - drug effects Cell Survival - drug effects DNA, Neoplasm - biosynthesis Flavonoids - pharmacology General aspects Human gastric cancer cell Humans Medical sciences Pharmacology. Drug treatments Quercetin Quercetin - administration & dosage Quercetin - pharmacology Starvation Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Tumor Cells, Cultured - drug effects |
| title | The effect of quercetin on cell cycle progression and growth of human gastric cancer cells |
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