Effect of Gallium Nitrate on Experimental Autoimmune Uveitis

Gallium nitrate (GN) has been shown to inhibit T cell-mediated inflammatory disease. The purpose of our study was to test the effect of gallium nitrate (GN) on experimental autoimmune uveitis (EAU). Experimental autoimmune uveitis was induced in male Lewis rats immunized with retinal S-antigen. Rats...

Full description

Saved in:
Bibliographic Details
Published in:Experimental eye research 1997-12, Vol.65 (6), p.797-801
Main Authors: LOBANOFF, MARK C., KOZHICH, ALEXANDER T., MULLET, DANIEL I., GERBER, NICHOLAS, GERY, IGAL, CHAN, CHI-CHAO, WHITCUP, SCOTT M.
Format: Article
Language:English
Subjects:
animal model
Animals
Antibody Formation - drug effects
Antineoplastic Agents - therapeutic use
Arrestin
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Autoimmune Diseases - prevention & control
autoimmunity
Biological and medical sciences
choroid
Choroid - pathology
experimental autoimmune uveitis
Eye
Gallium - therapeutic use
Gallium nitrate
Immunity, Cellular - drug effects
Immunization
inflammation
lymphocyte
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Inbred Lew
retina
Retina - pathology
uveitis
Uveitis - immunology
Uveitis - pathology
Uveitis - prevention & control
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gallium nitrate (GN) has been shown to inhibit T cell-mediated inflammatory disease. The purpose of our study was to test the effect of gallium nitrate (GN) on experimental autoimmune uveitis (EAU). Experimental autoimmune uveitis was induced in male Lewis rats immunized with retinal S-antigen. Rats received subcutaneous injections of GN or saline one day prior to immunization and 1, 4, 7, 10, 13, 16, and 19 days after immunization. Ocular inflammation was graded clinically and histologically by masked observers, and in vitro assays of cell-mediated and humoral immunity were performed. GN significantly inhibited the development of EAU graded clinically (P=0.001) and histologically (P=0.002). Treatment with GN also resulted in a small (30–41%) decrease in the lymphocyte responses to retinal S-Antigen and a small (12–37%) reduction in antibody production to S-antigen. These data show that GN suppresses the development of EAU, and inhibits both lymphocyte proliferative responses to antigen and antibody production.
ISSN:0014-4835
1096-0007
DOI:10.1006/exer.1997.0395