Widespread Cerebral Structural Changes in Two Patients with Gelastic Seizures and Hypothalamic Hamartomata

Purpose: We tested the hypothesis that widespread extralesional abnormalities of cerebral structure exist in association with apparently isolated hypothalamic hamartomata, providing a structural basis for the poor response of seizures to removal of the hamartoma or other apparently focal epilepto‐ge...

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Bibliographic Details
Published in:Epilepsia (Copenhagen) 1997-09, Vol.38 (9), p.1008-1010
Main Authors: Sisodiya, S. M., Free, S. L., Stevens, J. M., Fish, D. R., Shorvon, S. D.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain - abnormalities
Brain - pathology
Brain measurement
Cerebral dysgenesis
Epilepsy - diagnosis
Epilepsy - pathology
Epilepsy surgery
Hamartoma - diagnosis
Hamartoma - pathology
Humans
Hypothalamic hamartoma
Hypothalamic Neoplasms - diagnosis
Hypothalamic Neoplasms - pathology
Laughter
Magnetic Resonance Imaging
Male
Medical sciences
Neurology
Tumors of the nervous system. Phacomatoses
Volumetric magnetic resonance imaging
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Summary:Purpose: We tested the hypothesis that widespread extralesional abnormalities of cerebral structure exist in association with apparently isolated hypothalamic hamartomata, providing a structural basis for the poor response of seizures to removal of the hamartoma or other apparently focal epilepto‐genic zones present. Methods: High‐resolution magnetic resonance imaging (MRI) brain scans of 2 patients with hypothalamic hamartomata were quantified by determination of regional distribution and symmetry of distribution of cortical gray matter and subcortical matter volumes. The results were compared with normal ranges for the distribution of such tissues in 33 controls. Results: Both patients had abnormalities of distribution of gray and subcortical matter, whereas control subjects did not. These abnormalities were beyond the hamartoma itself, in areas of cerebrum that on visual inspection alone appeared completely normal. Conclusions: Extralesional abnormalities of cerebral structure are present in the cerebrum of patients with hypothalamic hamartoma, as in most patients with other dysgeneses. These abnormalities may explain the poor outcome of epilepsy surgery in patients with this form of dysgenesis. These preliminary findings require further investigation.
ISSN:0013-9580
1528-1167
DOI:10.1111/j.1528-1157.1997.tb01483.x