Synthetic strategies for the preparation of precursor polymers and of microcapsules suitable for cellular entrapment by polyelectrolyte complexation of those polymers

The production of microcapsules suitable for the entrapment of mammalian cell by means of polyelectrolyte complexation has, of a necessity, led to the development of novel strategies for the preparation of relatively bioinert polymers which complex efficiently under unique conditions to produce a me...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1997-12, Vol.831 (1), p.72-85
Main Authors: Dyakonov, T A, Zhou, L, Wan, Z, Huang, B, Meng, Z, Guo, X, Alexander, H, Moore, W V, Stevenson, W T
Format: Article
Language:English
Subjects:
Animals
Capsules - chemical synthesis
Drug Delivery Systems
Electrolytes
Humans
Models, Molecular
Polymers - chemical synthesis
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Summary:The production of microcapsules suitable for the entrapment of mammalian cell by means of polyelectrolyte complexation has, of a necessity, led to the development of novel strategies for the preparation of relatively bioinert polymers which complex efficiently under unique conditions to produce a mechanically resilient membrane with efficient transport properties. In this communication we relate a brief overview of capsule-membrane forming systems for the immunoisolation (or potential immunoisolation) of mammalian cells, which are based upon the complexation of polyelectrolyte (PE) polymers; with emphasis on precursor synthesis and relationships between precursor polymer structure and capsule membrane stability.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1997.tb52185.x