Polygenic control of the expression of biological activities of an antitumor polysaccharide, lentinan

Genetic studies were carried out on two in vivo responses of lentinan, delayed type-acute phase responses (DT-APR) and vascular dilation and hemorrhage (VDH). Linkage analyses showed that DT-APR was controlled by two recessive genes, ltnrl and ltnr2, which were mapped on chromosome 3 and 11, respect...

Full description

Saved in:
Bibliographic Details
Published in:International journal of immunopharmacology 1997-09, Vol.19 (9), p.469-472
Main Authors: Maeda, Yukiko Y., Takahama, Sumiyo, Kohara, Yuki, Yonekawa, Hiromichi
Format: Article
Language:English
Subjects:
acute phase response
Acute-Phase Reaction - etiology
Acute-Phase Reaction - genetics
Acute-Phase Reaction - immunology
Animals
Antineoplastic Agents - pharmacology
antitumor polysaccharide
Biological and medical sciences
Chromosome Mapping
Genes, Dominant
Genes, MHC Class II
Genes, Recessive
Genetic Linkage
Hemorrhage - etiology
Hemorrhage - genetics
Hemorrhage - immunology
Hypersensitivity, Delayed - etiology
Hypersensitivity, Delayed - genetics
Hypersensitivity, Delayed - immunology
Immunomodulators
lentinan
Lentinan - pharmacology
linkage analysis
Medical sciences
Mice
Mice, Inbred Strains
Pharmacology. Drug treatments
Species Specificity
Vasodilation - drug effects
Vasodilation - genetics
Vasodilation - immunology
VDH
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Genetic studies were carried out on two in vivo responses of lentinan, delayed type-acute phase responses (DT-APR) and vascular dilation and hemorrhage (VDH). Linkage analyses showed that DT-APR was controlled by two recessive genes, ltnrl and ltnr2, which were mapped on chromosome 3 and 11, respectively. VDH was also found to be controlled by polygenes. One dominant major gene, Ltnr3, and three dominant minor genes, Ltnr4, Ltnr5, and Ltnr6, were mapped on chromosomes 6, 9, 15 and 16, respectively.
ISSN:0192-0561
1879-3495
DOI:10.1016/S0192-0561(97)00082-9