2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A Neuroprotectant for Cerebral Ischemia

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the quinoxalinedione antagonists to the non-N-methyl-D-aspartate (non-NMDA) glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at t...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1990-02, Vol.247 (4942), p.571-574
Main Authors: Sheardown, Malcolm J., Nielsen, Elsebet Ø., Hansen, Anker J., Jacobsen, Poul, Honoré, Tage
Format: Article
Language:English
Subjects:
Agonists
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
AMPA receptors
Animals
Aspartic Acid - analogs & derivatives
Aspartic Acid - pharmacology
Biological and medical sciences
Brain
Brain ischemia
Brain Ischemia - drug therapy
Cerebral Cortex - drug effects
Cerebral Cortex - physiology
Dose response relationship
Excitatory amino acid antagonists
Hippocampus - drug effects
Hippocampus - physiology
Hippocampus - physiopathology
Ibotenic Acid - analogs & derivatives
Ibotenic Acid - pharmacology
In Vitro Techniques
Inhibitory concentration 50
Ischemia
Kainic Acid - pharmacology
Medical sciences
Miscellaneous
N-Methylaspartate
Neurons
Neurons - drug effects
Neurons - physiology
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Oxadiazoles - pharmacology
Pharmacology. Drug treatments
Pyramidal Tracts - drug effects
Pyramidal Tracts - physiology
Pyramidal Tracts - physiopathology
Quinoxalines - metabolism
Quinoxalines - pharmacology
Quinoxalines - therapeutic use
Quisqualic Acid
Rats
Receptors
Receptors, Glutamate
Receptors, Kainic Acid
Receptors, Neurotransmitter - drug effects
Receptors, Neurotransmitter - metabolism
Science
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Description
Summary:2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the quinoxalinedione antagonists to the non-N-methyl-D-aspartate (non-NMDA) glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine sites. NBQX protects against global ischemia, even when administered 2 hours after an ischemic challenge.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2154034