In-vitro activity of azithromycin compared with other macrolides and oral antibiotics against Salmonella typhi

The in-vitro activity of azithromycin against 60 clinical isolates of Salmonella typhi was determined by broth microdilution and compared with eight macrolides, including erythromycin, and with other orally administered antimicrobial agents (ampicillin, amoxycillin, cefaclor, trimethoprim/sulphameth...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1990, Vol.25 (suppl-A), p.29-31
Main Author: METCHOCK, B
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Azithromycin
Biological and medical sciences
Erythromycin - analogs & derivatives
Erythromycin - pharmacology
Medical sciences
Pharmacology. Drug treatments
Salmonella typhi - drug effects
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Summary:The in-vitro activity of azithromycin against 60 clinical isolates of Salmonella typhi was determined by broth microdilution and compared with eight macrolides, including erythromycin, and with other orally administered antimicrobial agents (ampicillin, amoxycillin, cefaclor, trimethoprim/sulphamethoxazole, chloramphenicol, tetracycline, and ciprofloxacin). Azithromycin was more potent (MIC range 4–16 mg/l; MIC90 8 mg/l) than erythromycin (MIC range 32- > 128 mg/l; MIC90, > 128 mg/l). Of the other macrolides, only rosaramkan showed increased activity against Salm. typhi (MIC range 16–32 mg/l; MIC90 32 mg/l) when compared with erythromycin. All 60 Salm. typhi were susceptible to ciprofloxacin (MIC < 0.5 mg/l). In 22 isolates, resistance to one or more of the following compounds occurred: ampicillin, amoxycillin, cefaclor, tetracycline, chloramphenicol, trimethoprim/sulphamethoxazole.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/25.suppl_A.29