Infectious pancreatic necrosis virus (IPNV) does not require acid compartments for entry into cells

The early events in the infection of unenveloped viruses are still rather unknown and puzzling. However, as in the case of enveloped viruses, the acid pH of endosomes can be important to trigger the virus entry into the cytosol. To test if the infectious pancreatic necrosis virus (IPNV), an unenvelo...

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Bibliographic Details
Published in:Archives of virology 1997, Vol.142 (11), p.2303-2308
Main Authors: Espinoza, J.C, Kuznar, J
Format: Article
Language:English
Subjects:
animal diseases
animal health
Animals
Anti-Bacterial Agents - pharmacology
aquatic organisms
Biological and medical sciences
Cell Line
Fundamental and applied biological sciences. Psychology
Hydrogen-Ion Concentration
Infectious pancreatic necrosis virus - drug effects
Infectious pancreatic necrosis virus - growth & development
Infectious pancreatic necrosis virus - physiology
Macrolides
Microbiology
Proton-Translocating ATPases - antagonists & inhibitors
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Salmon
trout infectious pancreatitis virus
viral diseases of animals and humans
Virology
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Summary:The early events in the infection of unenveloped viruses are still rather unknown and puzzling. However, as in the case of enveloped viruses, the acid pH of endosomes can be important to trigger the virus entry into the cytosol. To test if the infectious pancreatic necrosis virus (IPNV), an unenveloped virus, requires acid endosomal pH to infect cells, we assayed the effect of Bafilomycin A1 on IPNV replication. Concentrations of the antibiotic which inhibited the endosomal acidification of the host cells were unable to affect IPNV replication in CHSE-214 cells; therefore, the acid pH of endosomes seems not to be a mandatory condition for the entry of IPNV into cells.
ISSN:0304-8608
1432-8798
DOI:10.1007/s007050050244