CLINICAL CONCENTRATIONS OF VERAPAMIL AFFECT THE IN VITRO DIAGNOSIS OF SUSCEPTIBILITY TO MALIGNANT HYPERPYREXIA

We examined the effects of verapamil on the in vitro caffeine and halothane tests for malignant hyperpyrexia (MH) susceptibility. Ten consecutive MH-susceptible patients were investigated according to the protocol of the European MH group. Additional tests were carried out in the presence of verapam...

Full description

Saved in:
Bibliographic Details
Published in:British journal of anaesthesia : BJA 1990-01, Vol.64 (1), p.64-66
Main Authors: ADNET, P.J., KRIVOSIC-HORBER, R.M., ADAMANTIDIS, M.M., HAUDECOEUR, G., REYFORT, G.H., DUPUIS, B.A.
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Caffeine
Disease Susceptibility - diagnosis
False Negative Reactions
General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation
Halothane
Humans
In Vitro Techniques
Malignant hyperpyrexia
Malignant Hyperthermia - diagnosis
Medical sciences
Muscle Contraction - drug effects
Pharmacology: verapamil
Sensory Thresholds - drug effects
Verapamil - pharmacology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We examined the effects of verapamil on the in vitro caffeine and halothane tests for malignant hyperpyrexia (MH) susceptibility. Ten consecutive MH-susceptible patients were investigated according to the protocol of the European MH group. Additional tests were carried out in the presence of verapamil 10−6 mol litre−1. In four of the 10 patients, the halothane contracture response following pretreatment with verapamil was classified as positive to halothane. In contrast, in nine of the 10 patients, contracture tests of muscle in the presence of verapamil were classified as negative to caffeine. It is advised that verapamil should be discontinued before performing a contracture test.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/64.1.64