Nicotine induced ovarian and uterine changes in albino mice

Nicotine at the dose level of 0.3 mg/100 g body weight was administered to normal cycling mice for 15 days through oral and intraperitoneal routes. At autopsy on 16th day significant reduction in the ovarian and uterine weight was observed. Histological observations showed decrease in the number and...

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Bibliographic Details
Published in:Indian journal of physiology and pharmacology 1998-10, Vol.42 (4), p.503-508
Main Authors: Patil, S R, Ravindra, Londonkar, R, Patil, S B
Format: Article
Language:English
Subjects:
Animals
Cholesterol - analysis
Cholesterol - physiology
Female
Mice
Nicotine - pharmacology
Nicotinic Agonists - pharmacology
Organ Size - drug effects
Organ Size - physiology
Ovary - drug effects
Ovary - physiology
Proteins - analysis
Proteins - physiology
Uterus - drug effects
Uterus - physiology
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Summary:Nicotine at the dose level of 0.3 mg/100 g body weight was administered to normal cycling mice for 15 days through oral and intraperitoneal routes. At autopsy on 16th day significant reduction in the ovarian and uterine weight was observed. Histological observations showed decrease in the number and size of Graafian follicles, corpora lutea and increase in the atretic follicles in the ovary. The uterus showed absence of endometrial glands, decrease in the height of myometrium, endometrium and its epithelial cells. The total cholesterol content of the ovary and uterus is increased whereas the protein content is decreased. This antagonistic action of nicotine to gonadotrophins is discussed.
ISSN:0019-5499